Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pilocarpine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.97 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.97 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.97 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.97 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.97 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.97 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.97 |
| ▸ | CNR1 | P21554 | 1/20 | 0.97 |
| ▸ | HTR2A | P28223 | 1/20 | 0.97 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.97 |
| ▸ | MEN1 | O00255 | 1/20 | 0.97 |
| ▸ | USP2 | O75604 | 1/20 | 0.97 |
| ▸ | TP53 | P04637 | 1/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pilocarpine SCHEMBL725541 | 1.00 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL8370186 | 1.00 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL7076217 | 1.00 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL5504377 | 1.00 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL188019 | 0.99 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL15146 | 0.99 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL41890 | 0.99 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL9213198 | 0.99 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL678045 | 0.99 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL3078492 | 0.99 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 15132 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122030997-A | Spectral correction method and system for photon counting CT detector | 赛诺威盛科技(北京)股份有限公司 | 2026-05-15 | — | — | CN | claimed |
| US-20260124178-A1 | PRESBYOPIA TREATMENTS | ALLERGAN INC (US) | 2026-05-07 | — | — | US | claimed |
| US-20260116861-A1 | ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2026-04-30 | — | — | US | claimed |
| EP-4255560-B1 | KIT FOR TREATMENT OF PATIENTS HAVING DRY MOUTH SYNDROME | KOITE HEALTH OY (FI) | 2026-04-22 | — | — | EP | claimed |
| US-12522572-B2 | Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2026-01-13 | — | — | US | claimed |
| EP-4673538-A2 | COMPOSITIONS AND METHODS FOR PRODUCING GLYCOCONJUGATE POLYPEPTIDES HAVING ISOPEPTIDE BONDS WITH A SECOND POLYPEPTIDE PARTNER AND USES THEREOF | VAXNEWMO LLC (US) | 2026-01-07 | — | — | EP | claimed |
| US-20250382291-A1 | SUBSTITUTED PYRROLO[2,3-b]PYRIDINES FOR SUPPRESSING TOXIC ENDOPLASMIC RETICULUM STRESS | UNIV COLUMBIA (US) | 2025-12-18 | — | — | US | claimed |
| US-20250281407-A1 | LIPID DEPOT FORMULATIONS | CAMURUS AB (SE) | 2025-09-11 | — | — | US | claimed |
| US-12409166-B2 | Methods and compositions for oral pilocarpine liquid | RxOMEG Therapeutics LLC (US) | 2025-09-09 | — | — | US | claimed |
| US-20250268867-A1 | OPHTHALMIC PHARMACEUTICAL COMPOSITIONS AND USES RELATING THERETO | ORASIS PHARMACEUTICALS LTD (IL) | 2025-08-28 | — | — | US | claimed |
| US-4255415-A | COMPRISING A MEDICAMENT, A VINYL ACETATE-VINYL ALCOHOL COPOLYMER, AN ALKALI OR ALKALINE BORATE, AND STERILE WATER; TOPICAL | SCHERING CORPORATION (US) | 1981-03-10 | — | — | US | claimed |
| US-4209505-A | Pilocarpine mouthwash for dry mouth relief | MIKHAIL ADIB R | 1980-06-24 | — | — | US | claimed |
| US-4189491-A | THC ORALLY AND PILOCARPINE HYDROCHLORIDE OR ESINE TOPICALLY | CUENDET JEAN FRANCOIS | 1980-02-19 | — | — | US | claimed |
| US-4188373-A | Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes | COOPER LABORATORIES, INC. (US) | 1980-02-12 | — | — | US | claimed |
| US-4136178-A | POTENTIATION OF OPHTHALMIC DRUG | AMERICAN HOME PRODUCTS CORP. (US) | 1979-01-23 | — | — | US | claimed |
| US-4135514-A | Osmotic releasing system for administering ophthalmic drug to eye of animal | ALZA CORPORATION (US) | 1979-01-23 | — | — | US | claimed |
| US-4136177-A | FOR TOPICAL OPHTHALMIC USE, DRUG POTENTIATORS | AMERICAN HOME PRODUCTS CORP. (US) | 1979-01-23 | — | — | US | claimed |
| US-4136173-A | VEHICLES FOR OPHTHALMIC DRUGS | AMERICAN HOME PRODUCTS CORP. (US) | 1979-01-23 | — | — | US | claimed |
| US-4100271-A | Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes | COOPER LABORATORIES, INC. (US) | 1978-07-11 | — | — | US | claimed |
| US-3947573-A | POLYOXYETHYLENE GLYCOL | BURTON, PARSONS AND COMPANY, INC. (US) | 1976-03-30 | — | — | US | claimed |