Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pilocarpine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.97 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.97 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.97 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.97 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.97 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.97 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.97 |
| ▸ | CNR1 | P21554 | 1/20 | 0.97 |
| ▸ | HTR2A | P28223 | 1/20 | 0.97 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.97 |
| ▸ | MEN1 | O00255 | 1/20 | 0.97 |
| ▸ | USP2 | O75604 | 1/20 | 0.97 |
| ▸ | TP53 | P04637 | 1/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pilocarpine SCHEMBL725541 | 1.00 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL41427 | 1.00 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL8370186 | 1.00 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL5504377 | 1.00 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL188019 | 0.99 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL15146 | 0.99 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL41890 | 0.99 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL9213198 | 0.99 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL678045 | 0.99 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL3078492 | 0.99 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003084515-A1 | THERAPEUTIC AGENT DELIVERY COMPOSITIONS FOR BUCCAL CAVITY ABSORPTION OF PILOCARPINE | TRANSORAL PHARMACEUTICALS, INC. (US) | 2003-10-16 | — | — | WO | claimed |
| US-20030185884-A1 | Therapeutic agent delivery compositions for buccal cavity absorption of pilocarpine | TRANSORAL PHARMACEUTICALS, INC. | 2003-10-02 | — | — | US | claimed |
| WO-2003084515-A1 | THERAPEUTIC AGENT DELIVERY COMPOSITIONS FOR BUCCAL CAVITY ABSORPTION OF PILOCARPINE | TRANSORAL PHARMACEUTICALS, INC. (US) | 2003-10-16 | — | — | WO | disclosed |
| US-20030185884-A1 | Therapeutic agent delivery compositions for buccal cavity absorption of pilocarpine | TRANSORAL PHARMACEUTICALS, INC. | 2003-10-02 | — | — | US | disclosed |