Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pilocarpine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.97 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.97 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.97 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.97 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.97 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.97 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.97 |
| ▸ | CNR1 | P21554 | 1/20 | 0.97 |
| ▸ | HTR2A | P28223 | 1/20 | 0.97 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.97 |
| ▸ | MEN1 | O00255 | 1/20 | 0.97 |
| ▸ | USP2 | O75604 | 1/20 | 0.97 |
| ▸ | TP53 | P04637 | 1/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pilocarpine SCHEMBL41427 | 1.00 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL8370186 | 1.00 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL7076217 | 1.00 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL5504377 | 1.00 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL188019 | 0.99 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL15146 | 0.99 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL41890 | 0.99 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL9213198 | 0.99 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL678045 | 0.99 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 | |
| Pilocarpine SCHEMBL3078492 | 0.99 | LMNA (1.00) | LMNAKDM4EMAPTBLMPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480677-B8 | COMPOSITION FOR STABILIZING HYALURONIC ACID | CARL ZEISS MEDITEC SAS (FR) | 2012-05-23 | — | — | EP | claimed |
| EP-1480677-B1 | COMPOSITION FOR STABILIZING HYALURONIC ACID | IOLTECH (FR) | 2012-02-29 | — | — | EP | claimed |
| EP-0822822-A4 | CONTROLLED RELEASE OF MIOTIC AND MYDRIATIC DRUGS IN THE ANTERIOR CHAMBER | IOLTECH (FR) | 2006-01-11 | — | — | EP | claimed |
| EP-1027015-B1 | CONTROLLED RELEASE OF PHARMACEUTICALS IN THE ANTERIOR CHAMBER OF THE EYE | IOLTECH (FR) | 2005-02-09 | — | — | EP | claimed |
| EP-1480677-A2 | COMPOSITION FOR STABILIZING HYALURONIC ACID | IOLTECH (FR) | 2004-12-01 | — | — | EP | claimed |
| US-20030133986-A1 | Compositions for stabilizing poly (carboxylic acids) | TSAO FU-PAO (US) | 2003-07-17 | — | — | US | claimed |
| WO-2003043660-A2 | COMPOSITION FOR STABILIZING HYALURONIC ACID | NOVARTIS AG (CH) | 2003-05-30 | — | — | WO | claimed |
| US-5972326-A | Controlled release of pharmaceuticals in the anterior chamber of the eye | IOLTECH (FR) | 1999-10-26 | — | — | US | claimed |
| US-5759532-A | Controlled release of miotic and myriatic drugs in the anterior chamber | IOLTECH (FR) | 1998-06-02 | — | — | US | claimed |
| EP-0822822-A1 | CONTROLLED RELEASE OF MIOTIC AND MYDRIATIC DRUGS IN THE ANTERIOR CHAMBER | IOLTECH (FR) | 1998-02-11 | — | — | EP | claimed |
| WO-1996032951-A1 | CONTROLLED RELEASE OF MIOTIC AND MYDRIATIC DRUGS IN THE ANTERIOR CHAMBER | GALIN MILES A (US) | 1996-10-24 | — | — | WO | claimed |
| US-20150174112-A1 | COMPOSITIONS FOR TREATING FRAGILE X AND OTHER DISORDERS METHODS OF USE THEREOF, AND SCREENING FOR COMPOUNDS FOR FRAGILE X AND OTHER DISORDERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-06-25 | — | — | US | disclosed |
| EP-1480677-B8 | COMPOSITION FOR STABILIZING HYALURONIC ACID | CARL ZEISS MEDITEC SAS (FR) | 2012-05-23 | — | — | EP | disclosed |
| EP-1480677-B1 | COMPOSITION FOR STABILIZING HYALURONIC ACID | IOLTECH (FR) | 2012-02-29 | — | — | EP | disclosed |
| US-20080312279-A1 | Compositions for Treating Fragile X and Other Disorders Methods of Use Thereof, and Screening for Compounds for Fragile X and Other Disorders | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-12-18 | — | — | US | disclosed |
| US-5766580-A | Controlled release of miotic and mydriatic drugs in the anterior chamber | IOLTECH (FR) | 1998-06-16 | — | — | US | disclosed |
| US-5759532-A | Controlled release of miotic and myriatic drugs in the anterior chamber | IOLTECH (FR) | 1998-06-02 | — | — | US | disclosed |
| EP-0822822-A1 | CONTROLLED RELEASE OF MIOTIC AND MYDRIATIC DRUGS IN THE ANTERIOR CHAMBER | IOLTECH (FR) | 1998-02-11 | — | — | EP | disclosed |
| US-5612027-A | Controlled release of miotic and mydriatic drugs in the anterior chamber | IOLTECH (FR) | 1997-03-18 | — | — | US | disclosed |
| WO-1996032951-A1 | CONTROLLED RELEASE OF MIOTIC AND MYDRIATIC DRUGS IN THE ANTERIOR CHAMBER | GALIN MILES A (US) | 1996-10-24 | — | — | WO | disclosed |