Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pilocarpine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 1.00 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 3/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | CYP2A6 | P11509 | 1/20 | 1.00 |
| ▸ | CNR1 | P21554 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pilocarpine SCHEMBL188019 | 1.00 | LMNA (1.00) | LMNACYP3A4CHRM5CHRM4CHRM1 | |
| Pilocarpine SCHEMBL678045 | 1.00 | LMNA (1.00) | LMNACYP3A4CHRM5CHRM4CHRM1 | |
| Pilocarpine SCHEMBL9213198 | 1.00 | LMNA (1.00) | LMNACYP3A4CHRM5CHRM4CHRM1 | |
| Pilocarpine SCHEMBL15146 | 1.00 | LMNA (1.00) | LMNACYP3A4CHRM5CHRM4CHRM1 | |
| Pilocarpine SCHEMBL3078492 | 1.00 | LMNA (1.00) | LMNACYP3A4CHRM5CHRM4CHRM1 | |
| Pilocarpine SCHEMBL725541 | 0.99 | LMNA (1.00) | LMNACYP3A4CHRM5CHRM4CHRM1 | |
| Pilocarpine SCHEMBL1670751 | 0.99 | LMNA (0.97) | LMNACYP3A4CHRM5CHRM4CHRM1 | |
| Pilocarpine SCHEMBL5504377 | 0.99 | LMNA (1.00) | LMNACYP3A4CHRM5CHRM4CHRM1 | |
| Pilocarpine SCHEMBL7076217 | 0.99 | LMNA (1.00) | LMNACYP3A4CHRM5CHRM4CHRM1 | |
| Pilocarpine SCHEMBL4972337 | 0.99 | LMNA (0.97) | LMNACYP3A4CHRM5CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1593 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4724839-A2 | CONTACT LENSES INCLUDING MEDICAMENTS AND METHODS OF MAKING AND USING SAME INCLUDING SLOW RELEASE OF GLAUCOMA TREATING DRUGS AND COMFORT ENHANCING DRUGS | Mediprint Ophthalmics Inc. (US) | 2026-04-15 | — | — | EP | claimed |
| US-20260090984-A1 | CONTACT LENSES INCLUDING MEDICAMENTS AND METHODS OF MAKING AND USING SAME INCLUDING SLOW RELEASE OF GLAUCOMA TREATING DRUGS AND COMFORT ENHANCING DRUGS | MEDIPRINT OPHTHALMICS INC. (US) | 2026-04-02 | — | — | US | claimed |
| US-12390130-B2 | Wearable device for monitoring bodily fluids | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2025-08-19 | — | — | US | claimed |
| EP-4565206-A1 | OPHTHALMIC COMPOSITION COMPRISING PILOCARPINE AND A REDNESS REDUCTION AGENT | Bausch + Lomb Ireland Limited (IE) | 2025-06-11 | — | — | EP | claimed |
| EP-4555375-A1 | METHODS OF MAKING AND USING CONTACT LENSES INCLUDING MEDICAMENTS AND STABILIZERS OF LABILE COMPONENTS SUCH AS DRUGS | Doshi, Praful (US) | 2025-05-21 | — | — | EP | claimed |
| US-20250127760-A1 | COMPOSITION AND USE THEREOF IN PREPARATION OF MEDICAMENT FOR TREATING PRESBYOPIA | SHENYANG XINGQI PHARMACEUTICAL CO., LTD. (CN) | 2025-04-24 | — | — | US | claimed |
| CN-119595727-A | Preparation method of electrochemical biosensor for multi-mode sweat detection | 华南理工大学 | 2025-03-11 | — | — | CN | claimed |
| CN-118592895-B | Anti-pollution wearable sweat sensor based on phase transition protein composite hydrogel and preparation method and application thereof | 青岛科技大学 | 2025-02-11 | — | — | CN | claimed |
| CN-116350790-B | Composition and application thereof in preparation of medicine for treating presbyopia | 沈阳兴齐眼药股份有限公司 | 2025-02-07 | — | — | CN | claimed |
| US-12178904-B2 | Contact lenses including medicaments and methods of making and using same including stabilizers of labile components such as drugs | MEDIPRINT OPHTHALMICS INC. | 2024-12-31 | — | — | US | claimed |
| EP-0060451-B1 | IONTOPHORETIC ELECTRODE | MEDTRONIC, INC. (US) | 1986-09-17 | — | — | EP | claimed |
| EP-0138572-A2 | Hyaluronic acid fractions having pharmaceutical activity, methods for preparation thereof, and pharmaceutical compositions containing the same | FIDIA S.p.A. (IT) | 1985-04-24 | — | — | EP | claimed |
| EP-0060451-A1 | Iontophoretic electrode | MEDTRONIC, INC. (US) | 1982-09-22 | — | — | EP | claimed |
| EP-0056420-A1 | Ophthalmic gel | SCHERING CORPORATION (US) | 1982-07-28 | — | — | EP | claimed |
| US-4281654-A | Drug delivery system for controlled ocular therapy | ALZA CORPORATION (US) | 1981-08-04 | — | — | US | claimed |
| US-4255415-A | COMPRISING A MEDICAMENT, A VINYL ACETATE-VINYL ALCOHOL COPOLYMER, AN ALKALI OR ALKALINE BORATE, AND STERILE WATER; TOPICAL | SCHERING CORPORATION (US) | 1981-03-10 | — | — | US | claimed |
| US-4209505-A | Pilocarpine mouthwash for dry mouth relief | MIKHAIL ADIB R | 1980-06-24 | — | — | US | claimed |
| US-4190642-A | Ocular therapeutic system for dispensing a medication formulation | ALZA CORPORATION (US) | 1980-02-26 | — | — | US | claimed |
| US-4177256-A | Osmotic bursting drug delivery device | ALZA CORPORATION (US) | 1979-12-04 | — | — | US | claimed |
| US-4135514-A | Osmotic releasing system for administering ophthalmic drug to eye of animal | ALZA CORPORATION (US) | 1979-01-23 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260090984-A1 | CONTACT LENSES INCLUDING MEDICAMENTS AND METHODS OF MAKING AND USING SAME INCLUDING SLOW RELEASE OF GLAUCOMA TREATING DRUGS AND COMFORT ENHANCING DRUGS | RPL26, PCTP, RPS24 | CHRM1 2455/4885CHRM3 1421/4885LMNA 1960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.