Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pilocarpine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 1.00 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 3/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | CYP2A6 | P11509 | 1/20 | 1.00 |
| ▸ | CNR1 | P21554 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pilocarpine SCHEMBL188019 | 1.00 | LMNA (1.00) | LMNACYP3A4CHRM5CHRM4CHRM1 | |
| Pilocarpine SCHEMBL678045 | 1.00 | LMNA (1.00) | LMNACYP3A4CHRM5CHRM4CHRM1 | |
| Pilocarpine SCHEMBL9213198 | 1.00 | LMNA (1.00) | LMNACYP3A4CHRM5CHRM4CHRM1 | |
| Pilocarpine SCHEMBL15146 | 1.00 | LMNA (1.00) | LMNACYP3A4CHRM5CHRM4CHRM1 | |
| Pilocarpine SCHEMBL41890 | 1.00 | LMNA (1.00) | LMNACYP3A4CHRM5CHRM4CHRM1 | |
| Pilocarpine SCHEMBL725541 | 0.99 | LMNA (1.00) | LMNACYP3A4CHRM5CHRM4CHRM1 | |
| Pilocarpine SCHEMBL1670751 | 0.99 | LMNA (0.97) | LMNACYP3A4CHRM5CHRM4CHRM1 | |
| Pilocarpine SCHEMBL5504377 | 0.99 | LMNA (1.00) | LMNACYP3A4CHRM5CHRM4CHRM1 | |
| Pilocarpine SCHEMBL7076217 | 0.99 | LMNA (1.00) | LMNACYP3A4CHRM5CHRM4CHRM1 | |
| Pilocarpine SCHEMBL4972337 | 0.99 | LMNA (0.97) | LMNACYP3A4CHRM5CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233941-A1 | Co-Crystals of Calixarenes and Biologically Active Molecules | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS (FR) | 2009-09-17 | — | — | US | claimed |
| CN-117567440-A | Synthesis method of cholinergic receptor agonist | 南京恒道医药科技股份有限公司 | 2024-02-20 | — | — | CN | disclosed |
| US-10933052-B2 | Compositions and methods for the treatment of eye disorders | CELLIX BIO PRIVATE LIMITED (IN) | 2021-03-02 | — | — | US | disclosed |
| US-20200179343-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF EYE DISORDERS | CELLIX BIO PRIVATE LTD (IN) | 2020-06-11 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |
| US-20090233941-A1 | Co-Crystals of Calixarenes and Biologically Active Molecules | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS (FR) | 2009-09-17 | — | — | US | disclosed |
| US-20090209615-A1 | INHIBITORS OF MATRIX METALLOPROTEINASES TO TREAT NEUROLOGICAL DISORDERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-08-20 | — | — | US | disclosed |
| EP-0559700-B1 | NOVEL PILOCARPINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | SANTEN OY (FI) | 2000-04-26 | — | — | EP | disclosed |
| US-5436350-A | Glaucoma treatment | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1995-07-25 | — | — | US | disclosed |
| EP-0642501-A1 | NOVEL PILOCARPINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | LEIRAS OY (FI) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993024466-A1 | NOVEL PILOCARPINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | LEIRAS OY (FI) | 1993-12-09 | — | — | WO | disclosed |
| US-4977176-A | Pilocarpine compounds which are used as pharmaceutical agents | SANDOZ LTD. (CH) | 1990-12-11 | — | — | US | disclosed |
| US-4835174-A | Pilocarpine derivatives | SANDOZ LTD. (CH) | 1989-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233941-A1 | Co-Crystals of Calixarenes and Biologically Active Molecules | CALU, CALD1, CALR | CHRM1 4051/4885CHRM3 2303/4885LMNA 1257/4885 |
| US-20200179343-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF EYE DISORDERS | ALDH1A2, XDH, PDE6D | CHRM1 1280/4885CHRM3 1409/4885LMNA 1111/4885 |
| US-20090209615-A1 | INHIBITORS OF MATRIX METALLOPROTEINASES TO TREAT NEUROLOGICAL DISORDERS | MMP9, MMP10, MMP17 | CHRM1 4049/4885CHRM3 3529/4885LMNA 1476/4885 |
| US-10933052-B2 | Compositions and methods for the treatment of eye disorders | ALDH1A2, XDH, PDE6D | CHRM1 1280/4885CHRM3 1409/4885LMNA 1111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.