Sugi Predict

Sugi Predict / Compounds / SCHEMBL4143463

SCHEMBL4143463

SCHEMBL4143463

c1ccc(C23OOC(c4ccccc4)(c4ccccc42)c2ccccc23)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CFTR P13569 1/20 0.50
▸ GOPC Q9HD26 1/20 0.50
▸ GAA P10253 2/20 0.36
▸ PKM P14618 1/20 0.36
▸ HSP90AA1 P07900 2/20 0.36
▸ LMNA P02545 4/20 0.35
▸ MEN1 O00255 2/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ SMN1; SMN2 Q16637 2/20 0.35
▸ POLB P06746 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ ESR1 P03372 1/20 0.35
▸ TP53 P04637 1/20 0.35
▸ TYMS P04818 1/20 0.35
▸ CYP3A4 P08684 1/20 0.35
▸ MAPT P10636 1/20 0.35
▸ ALOX15 P16050 1/20 0.35
▸ TSHR P16473 1/20 0.35
▸ ESR2 Q92731 1/20 0.35
▸ HSD17B10 Q99714 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30463421 1.00 CFTR (0.50) CFTRGOPCGAAPKMHSP90AA1
SCHEMBL7915738 0.83 CFTR (0.50) CFTRGOPCGAAPKMHSP90AA1
SCHEMBL86130 0.74 TSHR (0.41) CFTRGOPCGAALMNAMEN1
SCHEMBL11316338 0.69 CFTR (0.42) CFTRGOPC
SCHEMBL24794778 0.69 CFTR (0.38) CFTRGOPCGAALMNASMN1; SMN2
SCHEMBL19003667 0.69 CFTR (0.38) CFTRGOPCGAALMNASMN1; SMN2
SCHEMBL24840897 0.69 CFTR (0.38) CFTRGOPCGAALMNASMN1; SMN2
SCHEMBL19003668 0.69 CFTR (0.38) CFTRGOPCGAALMNASMN1; SMN2
SCHEMBL5480380 0.68 OPRM1 (0.41) MEN1KMT2AALDH1A1OPRM1CYP2C9
SCHEMBL3886398 0.67 CFTR (1.00) CFTRGOPCGAAPKMHSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9115138-B2 Porphyrin compounds comprising one or more pyridone moieties VENTANA RESEARCH CORPORATION 2015-08-25 — — US disclosed
US-9115138-B2 Porphyrin compounds comprising one or more pyridone moieties VENTANA RESEARCH CORPORATION 2015-08-25 — — US disclosed
US-8445683-B2 Porphyrin compounds comprising one or more pyridone moieties VENTANA RESEARCH CORPORATION 2013-05-21 — — US disclosed
US-8445683-B2 Porphyrin compounds comprising one or more pyridone moieties VENTANA RESEARCH CORPORATION 2013-05-21 — — US disclosed
US-20120115901-A1 PORPHYRIN COMPOUNDS COMPRISING ONE OR MORE PYRIDONE MOIETIES VENTANA RESEARCH CORPORATION 2012-05-10 — — US disclosed
US-7642215-B2 Chemically-resistant shelter coatings LOMBARDI JOHN 2010-01-05 — — US disclosed
US-7642215-B2 Chemically-resistant shelter coatings LOMBARDI JOHN 2010-01-05 — — US disclosed
US-20080153690-A1 CHEMICALLY-RESISTANT SHELTER COATINGS LOMBARDI JOHN L 2008-06-26 — — US disclosed
US-20080153690-A1 CHEMICALLY-RESISTANT SHELTER COATINGS LOMBARDI JOHN L 2008-06-26 — — US disclosed
US-7259122-B1 Chemically-resistant shelter coating LOMBARDI JOHN 2007-08-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120115901-A1 PORPHYRIN COMPOUNDS COMPRISING ONE OR MORE PYRIDONE MOIETIES PPOX, PNPO, HMBS CFTR 3597/4885GOPC 934/4885GAA 3580/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.