Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 4/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3792756 | 0.82 | KIF11 (0.50) | KIF11CCR2PTGS1PTGS2MAPT | |
| SCHEMBL14906059 | 0.81 | MCL1 (0.61) | KIF11CCR2PTGS1PTGS2MAPT | |
| SCHEMBL2760253 | 0.79 | MAPT (0.48) | KIF11CCR2PTGS1PTGS2MAPT | |
| SCHEMBL11560825 | 0.79 | MCL1 (0.59) | KIF11CCR2PTGS1PTGS2MAPT | |
| SCHEMBL905181 | 0.78 | CCR2 (0.54) | KIF11CCR2NR3C1PGRNR3C2 | |
| SCHEMBL11562620 | 0.78 | MAPT (0.47) | KIF11CCR2PTGS1PTGS2MAPT | |
| SCHEMBL13028793 | 0.78 | CA2 (0.41) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL4094789 | 0.78 | PTGS2 (0.44) | PTGS1PTGS2NR3C1PGRNR3C2 | |
| SCHEMBL29904743 | 0.78 | APP (0.54) | KIF11CCR2PTGS1PTGS2MAPT | |
| SCHEMBL17338420 | 0.78 | APP (0.54) | KIF11CCR2PTGS1PTGS2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846907-B2 | Spiro-condensed indoline derivatives as pesticides | SYNGENTA CROP PROTECTION LLC (US) | 2014-09-30 | — | — | US | disclosed |
| US-20130046091-A1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | SYNGENTA CROP PROTECTION LLC (US) | 2013-02-21 | — | — | US | disclosed |
| US-8299058-B2 | Spiro-condensed indoline derivatives as pesticides | SYNGENTA CROP PROTECTION LLC (US) | 2012-10-30 | — | — | US | disclosed |
| US-20120232070-A1 | Use of Indole Derivatives as Nurr-1 Activators for the Application Thereof as a Medicament for the Treatment of Parkinson's Disease | LABORATOIRES FOURNIER SA (FR) | 2012-09-13 | — | — | US | disclosed |
| US-20090042859-A1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-02-12 | — | — | US | disclosed |
| EP-1697376-B1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-06-18 | — | — | EP | disclosed |
| EP-1697376-A1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | Syngenta Participations AG (CH) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005061512-A1 | SPIRO-CONDENSED INDOLINE DERIVATES AS PESTICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232070-A1 | Use of Indole Derivatives as Nurr-1 Activators for the Application Thereof as a Medicament for the Treatment of Parkinson's Disease | NCOR1, NR0B1, MTNR1A | KIF11 2073/4885CCR2 729/4885PTGS1 1118/4885 |
| US-20090042859-A1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | CHRM1, CHRM2, RO60 | KIF11 2668/4885CCR2 368/4885PTGS1 956/4885 |
| US-20130046091-A1 | SPIRO-CONDENSED INDOLINE DERIVATIVES AS PESTICIDES | CHRM1, CHRM2, CHRM3 | KIF11 2673/4885CCR2 420/4885PTGS1 874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.