Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 2/20 | 0.56 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.56 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.56 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | HRH2 | P25021 | 3/20 | 0.37 |
| ▸ | HRH1 | P35367 | 3/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | ARG1 | P05089 | 1/20 | 0.36 |
| ▸ | ARG2 | P78540 | 1/20 | 0.36 |
| ▸ | LSS | P48449 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20648687 | 0.94 | GNAI3 (0.59) | GNAI3GNAO1GNAI1SPHK1GBA1 | |
| SCHEMBL25036354 | 0.92 | GNAO1 (0.62) | GNAI3GNAO1GNAI1SPHK1GBA1 | |
| SCHEMBL24913115 | 0.90 | GNAI3 (0.46) | GNAI3GNAO1GNAI1SPHK1GBA1 | |
| SCHEMBL856657 | 0.88 | GNAI3 (0.50) | GNAI3GNAO1GNAI1SPHK1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL856924 | 0.86 | GNAI3 (0.53) | GNAI3GNAO1GNAI1SPHK1SIGMAR1 | |
| SCHEMBL16625961 | 0.86 | GBA1 (0.42) | GNAI3GNAO1GNAI1GBA1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL6589106 | 0.82 | GNAO1 (0.59) | GNAI3GNAO1GNAI1SPHK1SIGMAR1 | |
| SCHEMBL20648690 | 0.82 | GNAI3 (0.46) | GNAI3GNAO1GNAI1SPHK1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8699673 | 0.82 | GNAO1 (0.59) | GNAI3GNAO1GNAI1SPHK1SIGMAR1 | |
| SCHEMBL8085875 | 0.82 | SIGMAR1 (0.57) | GBA1SIGMAR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8080665-B2 | Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2011-12-20 | — | — | US | disclosed |
| US-20090124660-A1 | Piperidine Compounds Useful as Malonyl-CoA Decarboxylase Inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-05-14 | — | — | US | disclosed |
| US-7449482-B2 | Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2008-11-11 | — | — | US | disclosed |
| EP-1653957-B1 | PIPERIDINE COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITORS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2008-07-09 | — | — | EP | disclosed |
| EP-1653957-A1 | PIPERIDINE COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005011693-A1 | PIPERIDINE COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-02-10 | — | — | WO | disclosed |
| US-20050032828-A1 | Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032828-A1 | Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors | ACACA, ACACB, PC | GNAI3 3259/4885GNAO1 3542/4885GNAI1 2728/4885 |
| US-20090124660-A1 | Piperidine Compounds Useful as Malonyl-CoA Decarboxylase Inhibitors | ACACA, ACACB, PC | GNAI3 3259/4885GNAO1 3542/4885GNAI1 2728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.