SCHEMBL4144499

SCHEMBL4144499

CC(C)(C)OC(=O)CNc1nc(-c2ccccc2)ncc1NC(=O)Cc1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PDE4B Q07343 7/20 0.45
WNT3A P56704 1/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
EGLN1 Q9GZT9 1/20 0.41
NPC1 O15118 1/20 0.41
LMNA P02545 1/20 0.41
PKM P14618 1/20 0.41
ADORA3 P0DMS8 3/20 0.40
CTNNB1 P35222 1/20 0.40
TCF7L2 Q9NQB0 1/20 0.40
TSHR P16473 1/20 0.39
CCNE1 P24864 1/20 0.39
CDK2 P24941 1/20 0.39
CDK5 Q00535 1/20 0.39
HPGD P15428 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4144494 0.99 PDE4B (0.44) PDE4BWNT3AMEN1KMT2AEGLN1
SCHEMBL4141910 0.88 TSHR (0.41) PDE4BMEN1KMT2ALMNAADORA3
Hydrochloric Acid SCHEMBL4141904 0.87 TSHR (0.40) PDE4BMEN1KMT2ALMNAADORA3
Hydrochloric Acid SCHEMBL4144562 0.81 EGLN1 (0.47) PDE4BWNT3AMEN1KMT2AEGLN1
Hydrochloric Acid SCHEMBL4141946 0.80 PDE4B (0.48) PDE4BWNT3AMEN1KMT2AEGLN1
SCHEMBL4132365 0.73 CCNE1 (0.49) PDE4BWNT3AMEN1KMT2AADORA3
SCHEMBL6178282 0.72 ELANE (0.51) MEN1KMT2A
SCHEMBL9551634 0.71 CRHBP (0.60) MEN1KMT2ANPC1LMNAPKM
Hydrochloric Acid SCHEMBL4140741 0.71 APP (0.53) PDE4BMEN1KMT2ALMNAPKM
SCHEMBL14719815 0.68 ALDH1A1 (0.52) MEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090005560-A1 PRODUCTION METHOD OF DIAMINOPYRIMIDINE COMPOUNDS AJINOMOTO CO. INC (JP) 2009-01-01 US disclosed
EP-2009003-A1 Production method of diaminopyrimidine compounds Ajinomoto Co., Inc. (JP) 2008-12-31 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090005560-A1 PRODUCTION METHOD OF DIAMINOPYRIMIDINE COMPOUNDS DPYD, DHPS, UMPS PDE4B 119/4885WNT3A 3434/4885MEN1 2530/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.