Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4154662 | 0.88 | FFAR1 (0.54) | HTR2AHTR2CKCNH2FFAR1SCN9A | |
| SCHEMBL4158621 | 0.83 | CA12 (0.51) | HTR2AHTR2CKCNH2ALDH1A1HPGD | |
| SCHEMBL4147377 | 0.78 | CYP19A1 (0.56) | ALDH1A1HPGDMEN1KMT2APPARG | |
| SCHEMBL27867018 | 0.73 | KDM4E (0.47) | HTR2AHTR2CKCNH2ALDH1A1HPGD | |
| SCHEMBL4066217 | 0.72 | HTR2A (0.54) | HTR2AHTR2CKCNH2ALDH1A1HPGD | |
| SCHEMBL4150984 | 0.72 | HTR2A (0.43) | HTR2AHTR2CKCNH2ALDH1A1HPGD | |
| SCHEMBL3390895 | 0.70 | HTR2A (0.51) | HTR2AHTR2CKCNH2ALDH1A1MAPT | |
| SCHEMBL23298986 | 0.70 | ALDH1A1 (0.62) | ALDH1A1HPGDMEN1THRBKMT2A | |
| SCHEMBL1993674 | 0.69 | HTR2A (0.50) | HTR2AHTR2CKCNH2ALDH1A1HPGD | |
| SCHEMBL778229 | 0.67 | HTR6 (0.70) | HTR2AHTR2CKCNH2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090012134-A1 | Arylsulfonyl Benzofused Heterocycles as 5-Ht2a Antagonists | CURTIS NEIL ROY | 2009-01-08 | — | — | US | claimed |
| US-20090012134-A1 | Arylsulfonyl Benzofused Heterocycles as 5-Ht2a Antagonists | CURTIS NEIL ROY | 2009-01-08 | — | — | US | disclosed |
| EP-1866300-A1 | ARYLSULFONYL BENZOFUSED HETEROCYCLES AS 5-HT2A ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006100519-A1 | ARYLSULFONYL BENZOFUSED HETEROCYCLES AS 5-HT2A ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 2006-09-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012134-A1 | Arylsulfonyl Benzofused Heterocycles as 5-Ht2a Antagonists | HTR2A, HTR2C, HTR2B | HTR2A 1/4885HTR2C 2/4885KCNH2 544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.