SCHEMBL415226

SCHEMBL415226

O=Cc1cccc(Oc2ccc(Cl)cc2)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.55
SMN1; SMN2 Q16637 2/20 0.55
ALDH1A1 P00352 2/20 0.55
NPC1 O15118 2/20 0.52
RAB9A P51151 2/20 0.52
MAPT P10636 2/20 0.52
KMT2A Q03164 2/20 0.52
GAA P10253 1/20 0.52
ADAMTS5 Q9UNA0 1/20 0.52
SRC P12931 1/20 0.49
ALOX5 P09917 1/20 0.47
HSD17B10 Q99714 1/20 0.47
TERT O14746 1/20 0.47
MAOA P21397 5/20 0.46
MAOB P27338 5/20 0.46
TDP1 Q9NUW8 1/20 0.45
MEN1 O00255 1/20 0.44
LMNA P02545 1/20 0.44
TLR4 O00206 1/20 0.44
TLR2 O60603 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30715071 1.00 HPGD (0.55) HPGDSMN1; SMN2ALDH1A1NPC1RAB9A
SCHEMBL11217503 1.00 HPGD (0.55) HPGDSMN1; SMN2ALDH1A1NPC1RAB9A
SCHEMBL6856729 0.91 SRC (0.56) SMN1; SMN2ALDH1A1NPC1RAB9AMAPT
SCHEMBL30758642 0.87 MAPT (0.54) HPGDSMN1; SMN2ALDH1A1NPC1RAB9A
SCHEMBL5508642 0.87 MAPT (0.54) HPGDSMN1; SMN2ALDH1A1NPC1RAB9A
SCHEMBL31599170 0.87 SRC (0.53) SMN1; SMN2ALDH1A1NPC1RAB9AMAPT
SCHEMBL6853633 0.87 SRC (0.53) SMN1; SMN2ALDH1A1NPC1RAB9AMAPT
SCHEMBL11222905 0.87 MAOB (0.59) ALDH1A1NPC1RAB9AMAPTKMT2A
SCHEMBL6849018 0.87 SRC (0.60) HPGDSMN1; SMN2ALDH1A1NPC1RAB9A
SCHEMBL30631693 0.87 SRC (0.60) HPGDSMN1; SMN2ALDH1A1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 243 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040132807-A1 Aurones as telomerase inhibitors PHARMACIA ITALIA SPA (IT) 2004-07-08 US claimed
EP-1381359-A1 AURONES AS TELOMERASE INHIBITORS Pharmacia Italia S.p.A. (IT) 2004-01-21 EP claimed
WO-2002083123-A1 AURONES AS TELOMERASE INHIBITORS PHARMACIA ITALIA SPA (IT) 2002-10-24 WO claimed
WO-2025229046-A1 SUBSTITUTED HYDROQUINOLINES FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME MOLIUS SAGLIK TEKNOLOJILERI ANONIM SIRKETI (TR) 2025-11-06 WO disclosed
EP-4644375-A1 SUBSTITUTED HYDROQUINOLINES FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME Molius Saglik Teknolojileri Anonim Sirketi (TR) 2025-11-05 EP disclosed
US-20250262205-A1 DUAL MAGL AND FAAH INHIBITORS LUNDBECK LA JOLLA RESEARCH CENTER, INC. (US) 2025-08-21 US disclosed
US-12318383-B2 Dual MAGL and FAAH inhibitors LUNDBECK LA JOLLA RESEARCH CENTER, INC. (US) 2025-06-03 US disclosed
EP-4424683-A2 DUAL MAGL AND FAAH INHIBITORS Lundbeck La Jolla Research Center, Inc. (US) 2024-09-04 EP disclosed
EP-3595665-B1 DUAL MAGL AND FAAH INHIBITORS LUNDBECK LA JOLLA RESEARCH CENTER INC (US) 2024-08-28 EP disclosed
CN-118271288-A Dual MAGL and FAAH inhibitors 灵北拉荷亚研究中心公司 2024-07-02 CN disclosed
CN-117736178-A Dual MAGL and FAAH inhibitors 灵北拉荷亚研究中心公司 2024-03-22 CN disclosed
US-4299839-A Novel pesticides and pesticidal compositions cyclopropanecarboxylates and pesticidal method KURARAY CO., LTD. (JP) 1981-11-10 US disclosed
EP-0003427-B1 PREPARATION OF M-(P-BROMOPHENOXY)BENZALDEHYDE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1981-10-14 EP disclosed
US-4293504-A Process for preparing optically active α-cyano-3-(4-halogenophenoxy)-benzyl 2-(4-chlorophenyl)isovalerate SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1981-10-06 US disclosed
US-4262117-A INTERMEDIATES FOR INSECTICIDAL-MITICIDAL PYRETHROIDS AMERICAN CYANAMID COMPANY (US) 1981-04-14 US disclosed
US-4220767-A HISTAMINE ANTAGONISTS SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1980-09-02 US disclosed
US-4212829-A Preparation of m-(p-bromophenoxy)benzaldehyde SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1980-07-15 US disclosed
EP-0008867-A2 Cyanovinyl pyrethroids, processes for the preparation of these compounds and pesticidal use of the cyanovinyl pyrethroids AMERICAN CYANAMID COMPANY (US) 1980-03-19 EP disclosed
US-4185103-A ANTAGONISTS SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1980-01-22 US disclosed
EP-0003427-A1 Preparation of m-(p-bromophenoxy)benzaldehyde SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1979-08-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250262205-A1 DUAL MAGL AND FAAH INHIBITORS FAAH, FAAH2, MAG HPGD 627/4885SMN1; SMN2 745/4885ALDH1A1 1891/4885
US-12318383-B2 Dual MAGL and FAAH inhibitors FAAH, FAAH2, MAG HPGD 627/4885SMN1; SMN2 745/4885ALDH1A1 1891/4885
US-20040132807-A1 Aurones as telomerase inhibitors TERT, TERF2, TERF2IP HPGD 3095/4885SMN1; SMN2 2455/4885ALDH1A1 1344/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.