Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.48 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.48 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.48 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.48 |
| ▸ | NT5E | P21589 | 7/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | PI4KA | P42356 | 1/20 | 0.47 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.47 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.47 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.47 |
| ▸ | SARS1 | P49591 | 1/20 | 0.46 |
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
| ▸ | IARS1 | P41252 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13926698 | 0.92 | RXFP1 (0.61) | RXFP1CA1CA2CA4CA9 | |
| SCHEMBL4160501 | 0.90 | RXFP1 (0.62) | RXFP1CA1CA2CA4CA9 | |
| SCHEMBL13099188 | 0.89 | RXFP1 (0.58) | RXFP1P2RX1P2RX3P2RX4PI4KA | |
| SCHEMBL13662861 | 0.88 | RXFP1 (0.78) | RXFP1P2RX1P2RX3P2RX4PI4KA | |
| SCHEMBL5052452 | 0.88 | RXFP1 (0.78) | RXFP1P2RX1P2RX3P2RX4PI4KA | |
| SCHEMBL8818666 | 0.86 | RXFP1 (0.47) | RXFP1ADORA1 | |
| SCHEMBL572479 | 0.84 | RXFP1 (0.60) | RXFP1CA1CA2CA4CA9 | |
| Water SCHEMBL9941081 | 0.84 | RXFP1 (0.61) | RXFP1P2RX1P2RX3P2RX4ADORA1 | |
| SCHEMBL22498863 | 0.83 | NT5E (0.67) | CA1CA2CA4CA9ADORA3 | |
| SCHEMBL29390167 | 0.83 | NT5E (0.67) | CA1CA2CA4CA9ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8633168-B2 | Inhibitors of S-adenosyl-L-methionine decarboxylase | GENZYME CORPORATION (US) | 2014-01-21 | — | — | US | disclosed |
| US-8633168-B2 | Inhibitors of S-adenosyl-L-methionine decarboxylase | GENZYME CORPORATION (US) | 2014-01-21 | — | — | US | disclosed |
| US-20100261668-A1 | INHIBITORS OF S-ADENOSYL-L-METHIONINE DECARBOXYLASE | GENZYME CORPORATION | 2010-10-14 | — | — | US | disclosed |
| US-20100261668-A1 | INHIBITORS OF S-ADENOSYL-L-METHIONINE DECARBOXYLASE | GENZYME CORPORATION | 2010-10-14 | — | — | US | disclosed |
| US-20090048203-A1 | SUBSTITUTED ADENINES AND THE USES THEREOF | ASTRAZENECA AB (SE) | 2009-02-19 | — | — | US | disclosed |
| US-20080132525-A1 | isoforms DNMT1 and DNMT3b2; for example: 2-amino-4-(((2S,3S,4R,5R)-3,4-dihydroxy-5-(6-(phenethylamino)-9H-purin-9-yl)-tetrahydrofuran-2-yl)methylthio)butanoic acid | METHYLGENE INC. (CA) | 2008-06-05 | — | — | US | disclosed |
| US-20080132525-A1 | isoforms DNMT1 and DNMT3b2; for example: 2-amino-4-(((2S,3S,4R,5R)-3,4-dihydroxy-5-(6-(phenethylamino)-9H-purin-9-yl)-tetrahydrofuran-2-yl)methylthio)butanoic acid | METHYLGENE INC. (CA) | 2008-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048203-A1 | SUBSTITUTED ADENINES AND THE USES THEREOF | HPRT1, APRT, NUDT1 | RXFP1 2979/4885CA1 4418/4885CA2 2974/4885 |
| US-20080132525-A1 | isoforms DNMT1 and DNMT3b2; for example: 2-amino-4-(((2S,3S,4R,5R)-3,4-dihydroxy-5-(6-(phenethylamino)-9H-purin-9-yl)-tetrahydrofuran-2-yl)methylthio)butanoic acid | DNMT3B, DNMT1, DNMT3L | RXFP1 4723/4885CA1 4093/4885CA2 3063/4885 |
| US-20100261668-A1 | INHIBITORS OF S-ADENOSYL-L-METHIONINE DECARBOXYLASE | AMD1, MAT1A, AHCY | RXFP1 4642/4885CA1 4755/4885CA2 4243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.