Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.47 |
| ▸ | DBH | P09172 | 2/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Orthocresol SCHEMBL28292682 | 0.80 | — | — | |
| SCHEMBL122963 | 0.80 | ALDH1A1 (0.60) | DBHMMP2ALDH1A1LMNAHSD17B10 | |
| Orthocresol SCHEMBL29395276 | 0.77 | — | — | |
| Orthocresol SCHEMBL8710164 | 0.77 | TRPA1 (0.60) | TRPA1ATMALDH1A1LMNAHSD17B10 | |
| Orthocresol SCHEMBL170162 | 0.77 | TRPA1 (0.60) | TRPA1ATMALDH1A1LMNAHSD17B10 | |
| Orthocresol SCHEMBL10419161 | 0.77 | TRPA1 (0.60) | TRPA1ATMALDH1A1LMNAHSD17B10 | |
| Orthocresol SCHEMBL16002 | 0.77 | — | — | |
| Orthocresol SCHEMBL300420 | 0.76 | TRPA1 (0.52) | TRPA1ATMCXCR2DBHMMP2 | |
| Orthocresol SCHEMBL27388034 | 0.76 | TRPA1 (0.52) | TRPA1ATMCXCR2DBHMMP2 | |
| Orthocresol SCHEMBL8995948 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0267378-B1 | TROPOLONE DERIVATIVES AS AN ANTI-MYCOPLASMA AGENT | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1992-11-04 | — | — | EP | claimed |
| EP-0267378-A2 | Tropolone derivatives as an anti-mycoplasma agent | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1988-05-18 | — | — | EP | claimed |
| US-9790158-B2 | Substituted tropolone derivatives and methods of use | UNIVERSITY OF CONNECTICUT (US) | 2017-10-17 | — | — | US | disclosed |
| US-20150166448-A1 | Substituted Tropolone Derivatives and Methods of Use | UNIVERSITY OF CONNECTICUT | 2015-06-18 | — | — | US | disclosed |
| US-20090081134-A1 | Oral Care Compositions Comprising Tropolone Compounds and Essential Oils and Methods of Using The Same | PAN PAULINE | 2009-03-26 | — | — | US | disclosed |
| EP-1536759-A1 | ORAL CARE COMPOSITION COMPRISING TROPOLONE COMPOUNDS AND ESSENTIAL OILS | Warner-Lambert Company LLC (US) | 2005-06-08 | — | — | EP | disclosed |
| US-20040185010-A1 | Oral care compositions comprising tropolone compounds and essential oils and methods of using the same | MCNEIL-PPC, INC | 2004-09-23 | — | — | US | disclosed |
| WO-2004012692-A1 | ORAL CARE COMPOSITION COMPRISING TROPOLONE COMPOUNDS AND ESSENTIAL OILS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-12 | — | — | WO | disclosed |
| US-6689342-B1 | DENTISTRY | WARNER-LAMBERT COMPANY | 2004-02-10 | — | — | US | disclosed |
| US-20040018154-A1 | ORAL CARE COMPOSITIONS COMPRISING TROPOLONE COMPOUNDS AND ESSENTIAL OILS AND METHODS OF USING THE SAME | MCNEIL-PPC, INC | 2004-01-29 | — | — | US | disclosed |
| CN-1061655-C | Method of manufacturing the cycloheptimidazole derivatives | KOTOBUKI SEIYAKU CO LTD (JP) | 2001-02-07 | — | — | CN | disclosed |
| CN-1127752-A | Method of manufacturing the cycloheptimidazole derivatives | KOTOBUKI SEIYAKU CO LTD (JP) | 1996-07-31 | — | — | CN | disclosed |
| US-5409947-A | Treating hypertension, congestive heart failure | KOTOBUKI SEIYAKU CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0267378-B1 | TROPOLONE DERIVATIVES AS AN ANTI-MYCOPLASMA AGENT | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |
| US-4950686-A | Anti-mycoplasma agent | SHIONOGI & CO., LTD. (JP) | 1990-08-21 | — | — | US | disclosed |
| EP-0267378-A2 | Tropolone derivatives as an anti-mycoplasma agent | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1988-05-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090081134-A1 | Oral Care Compositions Comprising Tropolone Compounds and Essential Oils and Methods of Using The Same | TMSB10, PIGS, TPM3 | TRPA1 523/4885ATM 3674/4885CXCR2 3251/4885 |
| US-20040185010-A1 | Oral care compositions comprising tropolone compounds and essential oils and methods of using the same | TMSB10, PIGS, TPM3 | TRPA1 523/4885ATM 3674/4885CXCR2 3251/4885 |
| US-20150166448-A1 | Substituted Tropolone Derivatives and Methods of Use | HDAC5, HDAC4, HDAC7 | TRPA1 4546/4885ATM 2741/4885CXCR2 4220/4885 |
| US-20040018154-A1 | ORAL CARE COMPOSITIONS COMPRISING TROPOLONE COMPOUNDS AND ESSENTIAL OILS AND METHODS OF USING THE SAME | TMSB10, PIGS, TPM3 | TRPA1 523/4885ATM 3674/4885CXCR2 3251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.