Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLOD2 | O00469 | 1/20 | 0.44 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.44 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | ALPI | P09923 | 1/20 | 0.36 |
| ▸ | ALPG | P10696 | 1/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4168853 | 0.97 | PLOD2 (0.46) | PLOD2PLOD3PLOD1EPHX2LMNA | |
| Trifluoroacetic Acid SCHEMBL4157968 | 0.83 | PADI4 (0.49) | PLOD2PLOD3PLOD1EPHX2LMNA | |
| SCHEMBL4168844 | 0.79 | PLOD2 (0.46) | PLOD2PLOD3PLOD1EPHX2LMNA | |
| SCHEMBL4166903 | 0.79 | CES1 (0.36) | CES1HDAC1HDAC2 | |
| Trifluoroacetic Acid SCHEMBL3502968 | 0.78 | POLQ (0.36) | PLOD2PLOD3PLOD1EPHX2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL4304781 | 0.77 | CES1 (0.50) | ALDH1A1CES1HDAC1HDAC2 | |
| SCHEMBL4174326 | 0.75 | KMT2A (0.52) | EPHX2LMNACYP2C9CYP2C19CES1 | |
| SCHEMBL4169033 | 0.74 | CES1 (0.52) | ALDH1A1CES1HDAC1HDAC2 | |
| SCHEMBL4159834 | 0.74 | EPHX2 (0.43) | PLOD2PLOD3PLOD1EPHX2LMNA | |
| SCHEMBL4169482 | 0.73 | ALDH1A1 (0.45) | PLOD2PLOD3PLOD1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | JONES PHILIP | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | HDAC5, HDAC1, HDAC11 | PLOD2 3354/4885PLOD3 3265/4885PLOD1 2475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.