Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.43 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.43 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4171437 | 0.86 | SIGMAR1 (0.47) | SMN1; SMN2 | |
| SCHEMBL4156142 | 0.84 | ROCK2 (0.38) | L3MBTL1HDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL4168844 | 0.83 | PLOD2 (0.46) | PLOD2PLOD3PLOD1HDAC3HDAC4 | |
| Trifluoroacetic Acid SCHEMBL4157968 | 0.81 | PADI4 (0.49) | PLOD2PLOD3PLOD1HDAC3HDAC4 | |
| SCHEMBL4174326 | 0.80 | KMT2A (0.52) | SMN1; SMN2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4159631 | 0.80 | HDAC4 (0.47) | ALDH1A1PLOD2PLOD3PLOD1L3MBTL1 | |
| SCHEMBL4159834 | 0.79 | EPHX2 (0.43) | ALDH1A1SMN1; SMN2PLOD2PLOD3PLOD1 | |
| SCHEMBL4158976 | 0.79 | HDAC4 (0.53) | ALDH1A1HTTHDAC3HDAC4HDAC1 | |
| SCHEMBL4159149 | 0.79 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2HTTHDAC3HDAC4 | |
| Trifluoroacetic Acid SCHEMBL4165152 | 0.77 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | JONES PHILIP | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | HDAC5, HDAC1, HDAC11 | ALDH1A1 320/4885SMN1; SMN2 1280/4885PLOD2 3354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.