Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
| ▸ | CTSB | P07858 | 2/20 | 0.42 |
| ▸ | CTSV | O60911 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4159834 | 0.85 | EPHX2 (0.43) | NPC1RAB9ASMN1; SMN2LMNAEPHX2 | |
| SCHEMBL4168844 | 0.82 | PLOD2 (0.46) | LMNAEPHX2HDAC3HDAC4HDAC1 | |
| Trifluoroacetic Acid SCHEMBL4157968 | 0.82 | PADI4 (0.49) | LMNAEPHX2HDAC3HDAC4HDAC1 | |
| Trifluoroacetic Acid SCHEMBL4165152 | 0.81 | ALDH1A1 (0.39) | KMT2ALMNAGRIA1CTSSHDAC3 | |
| SCHEMBL4169482 | 0.80 | ALDH1A1 (0.45) | RAB9ASMN1; SMN2HDAC3HDAC4HDAC1 | |
| SCHEMBL4159149 | 0.80 | ALDH1A1 (0.52) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4159631 | 0.79 | HDAC4 (0.47) | KMT2AMEN1LMNAMAPTHDAC3 | |
| Trifluoroacetic Acid SCHEMBL4171437 | 0.79 | SIGMAR1 (0.47) | SMN1; SMN2LMNAMAPT | |
| SCHEMBL4158976 | 0.79 | HDAC4 (0.53) | KMT2AMEN1HDAC3HDAC4HDAC1 | |
| SCHEMBL4156445 | 0.76 | CES1 (0.59) | KMT2ACES1HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | JONES PHILIP | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054448-A1 | Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors | HDAC5, HDAC1, HDAC11 | KMT2A 20/4885MEN1 3953/4885NPC1 1625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.