Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL28197410 | 1.00 | HCAR2 (0.36) | HCAR2THRBTP53ALDH1A1CYP3A4 | |
| Acrylic Acid SCHEMBL7578570 | 0.91 | THRB (0.40) | THRBTP53ALDH1A1CYP3A4MAPK1 | |
| Acetic Acid SCHEMBL11582719 | 0.89 | THRB (0.38) | THRBTP53ALDH1A1CYP3A4MAPK1 | |
| SCHEMBL4147384 | 0.87 | MEN1 (0.38) | THRBTP53ALDH1A1CYP3A4MAPK1 | |
| SCHEMBL38754 | 0.87 | MEN1 (0.38) | THRBTP53ALDH1A1CYP3A4MAPK1 | |
| SCHEMBL6889697 | 0.87 | ALDH1A1 (0.45) | HCAR2THRBTP53ALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL28795774 | 0.85 | MEN1 (0.36) | THRBTP53ALDH1A1CYP3A4MAPK1 | |
| Propane SCHEMBL2147540 | 0.85 | MEN1 (0.36) | THRBTP53ALDH1A1CYP3A4MAPK1 | |
| SCHEMBL15918000 | 0.85 | MEN1 (0.36) | THRBTP53ALDH1A1CYP3A4MAPK1 | |
| Methacrylic Acid SCHEMBL1637663 | 0.85 | THRB (0.35) | THRBTP53ALDH1A1CYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902803-B1 | A THERMOPLASTIC COMPOUND | PERSTORP AB (SE) | 2004-09-22 | — | — | EP | claimed |
| EP-1187868-B1 | HYPERBRANCHED DENDRITIC POLYETHER AND PROCESS FOR MANUFACTURE THEREOF | PERSTORP AB (SE) | 2004-07-07 | — | — | EP | claimed |
| US-6617418-B1 | Thermally initiated cationic ring-opening polymerization of an oxetane having at least one reactive group in addition to the oxetane ether; end groups are hydroxyl | PERSTORP AB (SE) | 2003-09-09 | — | — | US | claimed |
| EP-0788524-B1 | HYPERBRANCHED MACROMOLECULE OF POLYESTER TYPE | PERSTORP AB (SE) | 2003-02-05 | — | — | EP | claimed |
| US-6379683-B1 | LIPID CORE ENCAPSULATED WITH POLYMER | L'OREAL (FR) | 2002-04-30 | — | — | US | claimed |
| EP-1187868-A1 | HYPERBRANCHED DENDRITIC POLYETHER AND PROCESS FOR MANUFACTURE THEREOF | PERSTORP AB (SE) | 2002-03-20 | — | — | EP | claimed |
| EP-1034839-B1 | Nanocapsules based on dendritic polymers | OREAL (FR) | 2001-10-24 | — | — | EP | claimed |
| US-6225404-B1 | ADHESION, COMPATIBILITY | PERSTORP AB (SE) | 2001-05-01 | — | — | US | claimed |
| WO-2001012725-A1 | CURABLE ANTIMICROBIAL HYPERBRANCHED POLYMER COMPOSITIONS | NESTE CHEMICALS OY (FI) | 2001-02-22 | — | — | WO | claimed |
| WO-2000056802-A1 | HYPERBRANCHED DENDRITIC POLYETHER AND PROCESS FOR MANUFACTURE THEREOF | PERSTORP AB (SE) | 2000-09-28 | — | — | WO | claimed |
| US-6114458-A | STAR POLYMER COMPRISING DENDRITIC MACROMOLECULAR INITIATOR, AND CHAIN EXTENDER MONOMERS INCLUDING A LACTONE | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2000-09-05 | — | — | US | claimed |
| EP-0902803-A1 | A THERMOPLASTIC COMPOUND | PERSTORP AB (SE) | 1999-03-24 | — | — | EP | claimed |
| EP-0630389-B1 | DENDRITIC MACROMOLECULE, PROCESS FOR PREPARATION THEREOF AND USE THEREOF | PERSTORP AB (SE) | 1998-04-29 | — | — | EP | claimed |
| WO-1997045474-A1 | A THERMOPLASTIC COMPOUND | PERSTORP AB (SE) | 1997-12-04 | — | — | WO | claimed |
| US-5663247-A | POLYESTERS | PERSTORP AB (SE) | 1997-09-02 | — | — | US | claimed |
| EP-0788524-A1 | HYPERBRANCHED MACROMOLECULE OF POLYESTER TYPE | PERSTORP AB (SE) | 1997-08-13 | — | — | EP | claimed |
| WO-1996012754-A1 | HYPERBRANCHED MACROMOLECULE OF POLYESTER TYPE | PERSTORP AB (SE) | 1996-05-02 | — | — | WO | claimed |
| US-5418301-A | Alkyd resins | PERSTORP AB (SE) | 1995-05-23 | — | — | US | claimed |
| EP-0630389-A1 | DENDRITIC MACROMOLECULE, PROCESS FOR PREPARATION THEREOF AND USE THEREOF | PERSTORP AB (SE) | 1994-12-28 | — | — | EP | claimed |
| WO-1993017060-A1 | DENDRITIC MACROMOLECULE, PROCESS FOR PREPARATION THEREOF AND USE THEREOF | PERSTORP AB (SE) | 1993-09-02 | — | — | WO | claimed |