Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | RBP4 | P02753 | 8/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KCNT1 | Q5JUK3 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL4153114 | 0.96 | MAPT (0.59) | MAPTRBP4LMNAMAPK1KCNT1 | |
| Iodide SCHEMBL4152138 | 0.82 | MAPT (0.61) | MAPTRBP4LMNAMAPK1KCNT1 | |
| Iodide SCHEMBL4161671 | 0.81 | MAPT (0.69) | MAPTRBP4LMNAMAPK1KCNT1 | |
| Iodide SCHEMBL4152999 | 0.81 | ALDH1A1 (0.60) | MAPTLMNAMAPK1ALDH1A1KMT2A | |
| Iodide SCHEMBL4150132 | 0.80 | NPSR1 (0.56) | MAPTALDH1A1KMT2AMEN1 | |
| Iodide SCHEMBL4159942 | 0.76 | ALDH1A1 (0.58) | MAPTLMNAMAPK1ALDH1A1KMT2A | |
| Iodide SCHEMBL4160958 | 0.75 | MAPT (0.55) | MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL4301167 | 0.74 | MAPT (0.67) | MAPTRBP4LMNAMAPK1KCNT1 | |
| SCHEMBL4306582 | 0.73 | MAPT (0.73) | MAPTRBP4LMNAMAPK1KCNT1 | |
| Iodide SCHEMBL4162764 | 0.73 | LMNA (0.48) | MAPTLMNAALDH1A1KMT2ATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118303-A1 | SEROTONIN 5-HT3 RECEPTOR AGONIST | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2009-05-07 | — | — | US | disclosed |
| US-7485646-B2 | Serotonin 5-HT3 receptor agonist | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2009-02-03 | — | — | US | disclosed |
| US-20070265277-A1 | Serotonin 5-Ht3 Receptor Agonist | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2007-11-15 | — | — | US | disclosed |
| EP-1798227-A1 | SEROTONIN 5-HT3 RECEPTOR AGONIST | Research Foundation Itsuu Laboratory (JP) | 2007-06-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118303-A1 | SEROTONIN 5-HT3 RECEPTOR AGONIST | HTR3A, HTR7, HTR1A | MAPT 4268/4885RBP4 3590/4885LMNA 4295/4885 |
| US-20070265277-A1 | Serotonin 5-Ht3 Receptor Agonist | HTR3A, HTR7, HTR1A | MAPT 4268/4885RBP4 3590/4885LMNA 4295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.