Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.45 |
| ▸ | HTR1A | P08908 | 4/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.45 |
| ▸ | HRH1 | P35367 | 5/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4170864 | 0.93 | HRH1 (0.41) | HTR2AHTR1ADRD2HRH1NOTUM | |
| SCHEMBL13875278 | 0.81 | DRD2 (0.49) | HTR2AHTR1ADRD2MAPTMEN1 | |
| SCHEMBL8534761 | 0.81 | ALDH1A1 (0.52) | HTR1ANOTUMLMNAMAPTCYP2C19 | |
| SCHEMBL2877908 | 0.81 | HRH1 (0.45) | HTR2AHRH1LMNAMAPTCYP2C19 | |
| SCHEMBL924605 | 0.78 | HTR1A (0.43) | HTR2AHTR1ADRD2HRH1SLC6A15 | |
| SCHEMBL19838569 | 0.74 | CYP11B1 (0.44) | HRH1LMNACYP2C19MEN1TP53 | |
| SCHEMBL2880939 | 0.74 | OPRL1 (0.50) | HTR2AHRH1LMNAMAPTCYP2C19 | |
| SCHEMBL17211829 | 0.74 | CYP24A1 (0.44) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL2882382 | 0.73 | HRH1 (0.43) | HTR2AHRH1LMNAMAPTCYP2C19 | |
| SCHEMBL14062161 | 0.73 | CYP26A1 (0.55) | CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240368146-A1 | Morpholine-Containing & Piperazine-Containing CXCR4 Modulators and Uses Related Thereto | UNIV EMORY (US) | 2024-11-07 | — | — | US | disclosed |
| EP-4373485-A1 | CXCR4 MODULATORS AND USES RELATED THERETO | Emory University (US) | 2024-05-29 | — | — | EP | disclosed |
| WO-2023003862-A1 | CXCR4 MODULATORS AND USES RELATED THERETO | EMORY UNIVERSITY (US) | 2023-01-26 | — | — | WO | disclosed |
| US-20090093454-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2009-04-09 | — | — | US | disclosed |
| US-20090093454-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2009-04-09 | — | — | US | disclosed |
| US-20090093454-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2009-04-09 | — | — | US | disclosed |
| EP-1853604-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006096444-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-09-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240368146-A1 | Morpholine-Containing & Piperazine-Containing CXCR4 Modulators and Uses Related Thereto | CXCR4, CXCL12, MYD88 | HTR2A 674/4885HTR1A 1055/4885DRD2 1838/4885 |
| US-20090093454-A1 | Chemical Compounds | SLC10A1, CYP11B2, CYP4F3 | HTR2A 1676/4885HTR1A 1175/4885DRD2 2428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.