SCHEMBL4166540

SCHEMBL4166540

Cc1c(F)c(F)c(C(=O)N[C@@H](Cc2ccccc2)C(=O)O)c(F)c1F

nearest known ligand 0.68

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.68
NAALAD2 Q9Y3Q0 1/20 0.55
ALDH1A1 P00352 1/20 0.53
ITGA4 P13612 5/20 0.52
PTPN1 P18031 1/20 0.51
MME P08473 1/20 0.50
KMT2A Q03164 1/20 0.50
ITGB1 P05556 4/20 0.49
CA2 P00918 2/20 0.49
ACE P12821 2/20 0.49
CA1 P00915 1/20 0.49
NPSR1 Q6W5P4 1/20 0.49
ITGA2 P17301 1/20 0.48
ITGB7 P26010 1/20 0.48
FPR2 P25090 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28965814 0.91 L3MBTL1 (0.67) L3MBTL1NAALAD2ALDH1A1ITGA4PTPN1
SCHEMBL28965815 0.91 L3MBTL1 (0.67) L3MBTL1NAALAD2ALDH1A1ITGA4PTPN1
SCHEMBL4180754 0.88 ATM (0.59) L3MBTL1ALDH1A1KMT2A
SCHEMBL4170016 0.79 L3MBTL1 (0.79) L3MBTL1NAALAD2ITGA4PTPN1KMT2A
SCHEMBL15145361 0.78 L3MBTL1 (0.68) L3MBTL1NAALAD2ITGA4PTPN1MME
SCHEMBL1696507 0.77 MME (0.67) L3MBTL1NAALAD2PTPN1MMEACE
SCHEMBL547223 0.77 MME (0.67) L3MBTL1NAALAD2PTPN1MMEACE
SCHEMBL547222 0.77 MME (0.67) L3MBTL1NAALAD2PTPN1MMEACE
SCHEMBL18180178 0.77 NAALAD2 (0.78) L3MBTL1NAALAD2ALDH1A1MMEKMT2A
SCHEMBL19969196 0.77 NAALAD2 (0.78) L3MBTL1NAALAD2ALDH1A1MMEKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090047379-A1 Benzamide Compounds Useful as High Potency Sweet Taste Enhancers DEWIS MARK L 2009-02-19 US disclosed
US-20090047379-A1 Benzamide Compounds Useful as High Potency Sweet Taste Enhancers DEWIS MARK L 2009-02-19 US disclosed
US-20090047379-A1 Benzamide Compounds Useful as High Potency Sweet Taste Enhancers DEWIS MARK L 2009-02-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090047379-A1 Benzamide Compounds Useful as High Potency Sweet Taste Enhancers TAS2R10, TAS2R50, TAS2R8 L3MBTL1 4231/4885NAALAD2 396/4885ALDH1A1 818/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.