Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8237354 | 0.97 | KEAP1 (0.48) | KEAP1NFE2L2KDM4EENPP2HTT | |
| SCHEMBL28330143 | 0.86 | KDM4E (0.54) | KEAP1NFE2L2KDM4ETDP1GAA | |
| SCHEMBL28331567 | 0.80 | MMP3 (0.55) | KEAP1NFE2L2KDM4EHTTSMN1; SMN2 | |
| SCHEMBL4174306 | 0.76 | ALDH1A1 (0.47) | KEAP1NFE2L2KDM4EENPP2SMN1; SMN2 | |
| SCHEMBL18282366 | 0.75 | HTT (0.72) | KEAP1NFE2L2ENPP2HTTSMN1; SMN2 | |
| SCHEMBL28246862 | 0.75 | NPC1 (0.50) | KDM4EHTTSMN1; SMN2TDP1MEN1 | |
| SCHEMBL16714258 | 0.75 | HTT (0.67) | KEAP1NFE2L2ENPP2HTTSMN1; SMN2 | |
| SCHEMBL30041498 | 0.74 | KDM4E (0.50) | KEAP1NFE2L2KDM4EGAAALDH1A1 | |
| SCHEMBL6572241 | 0.74 | KDM4E (0.50) | KEAP1NFE2L2KDM4EGAAALDH1A1 | |
| SCHEMBL28330248 | 0.74 | FAAH (0.43) | KDM4ESMN1; SMN2MEN1KMT2APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090017112-A1 | Compounds for Inhibiting Beta-Amyloid Production | ROSKAMP RESEARCH LLC (US) | 2009-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090017112-A1 | Compounds for Inhibiting Beta-Amyloid Production | PSEN1, PSEN2, APP | KEAP1 684/4885NFE2L2 820/4885KDM4E 4787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.