Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.55 |
| ▸ | ANPEP | P15144 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ELANE | P08246 | 1/20 | 0.48 |
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4166663 | 1.00 | TRPM8 (0.55) | TRPM8ANPEPALDH1A1MAPTL3MBTL1 | |
| SCHEMBL13915548 | 1.00 | TRPM8 (0.55) | TRPM8ANPEPALDH1A1MAPTL3MBTL1 | |
| SCHEMBL5658130 | 0.87 | ANPEP (0.57) | ANPEPALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL8069933 | 0.87 | ANPEP (0.57) | ANPEPALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL5658127 | 0.87 | ANPEP (0.57) | ANPEPALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL18782332 | 0.87 | ANPEP (0.57) | ANPEPALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL28322266 | 0.87 | TRPM8 (0.54) | TRPM8ANPEPALDH1A1MAPTL3MBTL1 | |
| SCHEMBL24326690 | 0.86 | TRPM8 (0.59) | TRPM8ANPEPALDH1A1MAPTL3MBTL1 | |
| SCHEMBL1889631 | 0.86 | TRPM8 (0.59) | TRPM8ANPEPALDH1A1MAPTL3MBTL1 | |
| SCHEMBL1889629 | 0.86 | TRPM8 (0.59) | TRPM8ANPEPALDH1A1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12152048-B2 | Nitroxoline prodrug and use thereof | JIANGSU YAHONG MEDITECH CO., LTD. (CN) | 2024-11-26 | — | — | US | disclosed |
| US-20210363165-A1 | NITROXOLINE PRODRUG AND USE THEREOF | JIANGSU YAHONG MEDITECH CO., LTD. (CN) | 2021-11-25 | — | — | US | disclosed |
| US-20210363165-A1 | NITROXOLINE PRODRUG AND USE THEREOF | JIANGSU YAHONG MEDITECH CO., LTD. (CN) | 2021-11-25 | — | — | US | disclosed |
| EP-3858814-A1 | NITROXOLINE PRODRUG AND USE THEREOF | Jiangsu Yahong Meditech Co., Ltd. (CN) | 2021-08-04 | — | — | EP | disclosed |
| EP-3858814-A1 | NITROXOLINE PRODRUG AND USE THEREOF | Jiangsu Yahong Meditech Co., Ltd. (CN) | 2021-08-04 | — | — | EP | disclosed |
| CN-111295372-B | Nitroxoline prodrugs and uses thereof | 江苏亚虹医药科技股份有限公司 | 2021-03-09 | — | — | CN | disclosed |
| CN-111295372-A | Nitroxoline prodrugs and uses thereof | 江苏亚虹医药科技有限公司 | 2020-06-16 | — | — | CN | disclosed |
| WO-2020063824-A1 | NITROXOLINE PRODRUG AND USE THEREOF | 江苏亚虹医药科技有限公司 | 2020-04-02 | — | — | WO | disclosed |
| US-8552208-B2 | Analogs of tetramic acid | University of Tennesseee Research Foundation (US) | 2013-10-08 | — | — | US | disclosed |
| US-20090069406-A1 | Analogs of tetramic acid | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12152048-B2 | Nitroxoline prodrug and use thereof | NOS1, NOS2, NNT | TRPM8 3143/4885ANPEP 796/4885ALDH1A1 706/4885 |
| US-20210363165-A1 | NITROXOLINE PRODRUG AND USE THEREOF | NOS1, NOS2, NNT | TRPM8 3143/4885ANPEP 796/4885ALDH1A1 706/4885 |
| US-20090069406-A1 | Analogs of tetramic acid | TFRC, SLC7A1, FTH1 | TRPM8 1477/4885ANPEP 948/4885ALDH1A1 2743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.