Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | MAN2B1 | O00754 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4178092 | 0.91 | SIGMAR1 (0.35) | SIGMAR1BRD4CNR2ALDH1A1MEN1 | |
| SCHEMBL4172529 | 0.89 | BRD4 (0.35) | SIGMAR1BRD4CNR2ALDH1A1MEN1 | |
| SCHEMBL3975810 | 0.85 | MTNR1A (0.41) | SIGMAR1ALDH1A1MEN1CYP1A2CYP2D6 | |
| SCHEMBL5433728 | 0.83 | SIGMAR1 (0.40) | SIGMAR1ALDH1A1MEN1CYP1A2KMT2A | |
| SCHEMBL5435573 | 0.82 | SIGMAR1 (0.40) | SIGMAR1ALDH1A1MEN1CYP1A2KMT2A | |
| SCHEMBL4169255 | 0.82 | SIGMAR1 (0.38) | SIGMAR1BRD4CNR2ALDH1A1CYP2D6 | |
| SCHEMBL5433734 | 0.81 | SIGMAR1 (0.40) | SIGMAR1ALDH1A1MEN1CYP1A2KMT2A | |
| SCHEMBL4183931 | 0.79 | SIGMAR1 (0.37) | SIGMAR1CNR2MEN1CYP2D6CYP2C19 | |
| Trifluoroacetic Acid SCHEMBL4183630 | 0.78 | KDM4E (0.34) | ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL4183936 | 0.78 | SIGMAR1 (0.37) | SIGMAR1CNR2MEN1CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090062218-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2009-03-05 | — | — | US | disclosed |
| US-20080096829-A1 | Macrolone Compounds | GLAXO GROUP LIMITED (GB) | 2008-04-24 | — | — | US | disclosed |
| EP-1824871-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006050940-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2006-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062218-A1 | MACROLONE COMPOUNDS | CYP51A1, MRPL21, MYD88 | SIGMAR1 1925/4885BRD4 2030/4885CNR2 4419/4885 |
| US-20080096829-A1 | Macrolone Compounds | MRPL21, MRPS18A, MRPL19 | SIGMAR1 601/4885BRD4 3197/4885CNR2 4739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.