Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.50 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.50 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.50 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.50 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL59198 | 0.89 | KEAP1 (0.65) | KEAP1FFAR1PTGER1PTGER4PTGER3 | |
| SCHEMBL19140662 | 0.88 | FOLH1 (0.60) | KEAP1FFAR1PTGER1PTGER4PTGER3 | |
| SCHEMBL3728799 | 0.81 | CYP4F2 (0.58) | KEAP1FFAR1PTGER1PTGER4PTGER3 | |
| SCHEMBL8019696 | 0.81 | AKR1B1 (0.59) | KEAP1FFAR1PTGER1PTGER4PTGER3 | |
| SCHEMBL8573204 | 0.81 | KEAP1 (0.56) | KEAP1FFAR1PTGER1PTGER4PTGER3 | |
| SCHEMBL878984 | 0.81 | KEAP1 (0.56) | KEAP1FFAR1PTGER1PTGER4PTGER3 | |
| SCHEMBL8851286 | 0.79 | KEAP1 (0.54) | KEAP1FFAR1PTGER1PTGER4PTGER3 | |
| SCHEMBL22826567 | 0.79 | MAPT (0.62) | KEAP1FFAR1PTGER1PTGER4PTGER3 | |
| SCHEMBL10576803 | 0.79 | KEAP1 (0.54) | KEAP1FFAR1PTGER1PTGER4PTGER3 | |
| SCHEMBL8109289 | 0.79 | KEAP1 (0.54) | KEAP1FFAR1PTGER1PTGER4PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8247608-B2 | Aminoacid derivatives containing a disulfanyl group in the form of mixed disulfanyl and aminopeptidase N inhibitors | PHARMALEADS (FR) | 2012-08-21 | — | — | US | disclosed |
| US-8247609-B2 | Aminoacid derivatives containing a disulfanyl group in the form of mixed disulfanyl and aminopeptidase N inhibitors | Pharamleads (FR) | 2012-08-21 | — | — | US | disclosed |
| US-20090131509-A1 | Aminoacid Derivatives Containing a Disulfanyl Group in the form of Mixed Disulfanyl and Aminopeptidase N Inhibitors | PHARMALEADS (FR) | 2009-05-21 | — | — | US | disclosed |
| US-20090012153-A1 | AMINOACID DERIVATIVES CONTAINING A DISULFANYL GROUP IN THE FORM OF MIXED DISULFANYL AND AMINOPEPTIDASE N INHIBITORS | PHARMALEADS (FR) | 2009-01-08 | — | — | US | disclosed |
| US-6013829-A | REDUCING A MALONIC DIESTER, HYDRIDING TO OBTAIN A DIOL, ACETYLATING TO OBTAIN A MONOESTER, OXIDATION, SAPONIFICATION AND THIOACYLATING; ENZYME INHIBITORS; PROTEASES; OPTICS; ANTISECRETORY AND HYPOTENSIVE AGENTS | SOCIETE CIVILE BIOPROJET (FR) | 2000-01-11 | — | — | US | disclosed |
| US-5684185-A | MULTISTAGE REACTION OF SULFIDING, REACTION WITH YLIDE, HYDROLYSIS, HYDROGENATION AND OXIDATION | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-11-04 | — | — | US | disclosed |
| US-5554788-A | PROTEASE INHIBITORS | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131509-A1 | Aminoacid Derivatives Containing a Disulfanyl Group in the form of Mixed Disulfanyl and Aminopeptidase N Inhibitors | HRH4, OPRL1, CNR2 | KEAP1 2113/4885FFAR1 430/4885PTGER1 521/4885 |
| US-20090012153-A1 | AMINOACID DERIVATIVES CONTAINING A DISULFANYL GROUP IN THE FORM OF MIXED DISULFANYL AND AMINOPEPTIDASE N INHIBITORS | HRH4, CNR2, OPRM1 | KEAP1 2019/4885FFAR1 402/4885PTGER1 611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.