Sulofenur

Sulofenur

SCHEMBL4174

O=C(Nc1ccc(Cl)cc1)NS(=O)(=O)c1ccc2c(c1)CCC2

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KCNA1 Q09470 5/20 0.65
KCNAB1 Q14722 5/20 0.65
CA12 O43570 3/20 0.57
CA1 P00915 3/20 0.57
CA2 P00918 3/20 0.57
CA9 Q16790 3/20 0.57
NPC1 O15118 3/20 0.50
RAB9A P51151 3/20 0.50
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
LMNA P02545 1/20 0.50
FBP1 P09467 1/20 0.49
POLB P06746 1/20 0.49
NLRP3 Q96P20 1/20 0.48
PNMT P11086 1/20 0.48
PTPN7 P35236 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sulofenur SCHEMBL29359159 1.00 KCNA1 (0.65) KCNA1KCNAB1CA12CA1CA2
SCHEMBL8878995 0.97 KCNA1 (0.65) KCNA1KCNAB1CA12CA1CA2
SCHEMBL8794803 0.88 CA12 (0.55) KCNA1KCNAB1CA12CA1CA2
SCHEMBL8879166 0.88 KCNA1 (0.56) KCNA1KCNAB1CA12CA1CA2
SCHEMBL15865553 0.87 RAB9A (0.67) KCNA1KCNAB1CA12CA1CA2
SCHEMBL28766991 0.87 NPC1 (0.67) KCNA1KCNAB1CA12CA1CA2
Sulofenur SCHEMBL8376567 0.87 KCNA1 (0.52) KCNA1KCNAB1CA12CA1CA2
SCHEMBL8793567 0.84 CA12 (0.52) KCNA1KCNAB1CA12CA1CA2
SCHEMBL10698263 0.84 KCNA1 (0.55) KCNA1KCNAB1CA12CA1CA2
SCHEMBL9486495 0.82 CA12 (0.66) KCNA1KCNAB1CA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 10447 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260116861-A1 ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-04-30 US claimed
US-12522572-B2 Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-01-13 US claimed
EP-4524131-A1 SMALL MOLECULES FOR TREATING CANCER, INHABITING CHEMOKINE ACTIVITY AND/OR INDUCING CELL DEATH AlonBio Ltd. (IL) 2025-03-19 EP claimed
US-12202803-B2 Small molecules for treating cancer, inhibiting chemokine activity and/or inducing cell death ALONBIO LTD. (IL) 2025-01-21 US claimed
US-20240343697-A1 ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2024-10-17 US claimed
US-12109219-B2 Cannabinoid receptor modulators ARENA PHARMACEUTICALS, INC. (US) 2024-10-08 US claimed
EP-4401780-A1 AMORPHOUS PHOTOSENSITIZING PARTICLES, METHODS FOR THE PREPARATION THEREOF, AND METHODS FOR THE USE THEREOF University of Maryland, College Park (US) 2024-07-24 EP claimed
WO-2024026505-A2 DISRUPTION OF TELOCYTE ACTIVITY PATEL AMIT (US) 2024-02-01 WO claimed
US-20240002347-A1 SMALL MOLECULES FOR TREATING CANCER, INHIBITING CHEMOKINE ACTIVITY AND/OR INDUCING CELL DEATH ALONBIO LTD. (IL) 2024-01-04 US claimed
EP-2796112-B2 Degradable implantable medical devices ELIXIR MEDICAL CORP (US) 2023-08-09 EP claimed
EP-1019034-A2 ANTIOXIDANT ENHANCEMENT OF THERAPY FOR HYPERPROLIFERATIVE CONDITIONS Atherogenics, Inc. (US) 2000-07-19 EP claimed
WO-1999039732-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING PEG-ASPARAGINASE FOR THE TREATMENT OF HIV INFECTIONS AVENTIS PHARMACEUTICALS PRODUCTS INC. (US) 1999-08-12 WO claimed
WO-1999001118-A9 ANTIOXIDANT ENHANCEMENT OF THERAPY FOR HYPERPROLIFERATIVE CONDITIONS ATHEROGENICS INC (US) 1999-05-20 WO claimed
WO-1999001118-A2 ANTIOXIDANT ENHANCEMENT OF THERAPY FOR HYPERPROLIFERATIVE CONDITIONS ATHEROGENICS, INC. (US) 1999-01-14 WO claimed
EP-0382411-B1 Delivery of cytotoxic agents LILLY CO ELI (US) 1994-12-07 EP claimed
US-5116874-A Aminocarbonyl sulfonamide derivatives ELI LILLY AND COMPANY (US) 1992-05-26 US claimed
EP-0382411-A2 Delivery of cytotoxic agents ELI LILLY AND COMPANY (US) 1990-08-16 EP claimed
EP-0222475-B1 SULFONYL UREAS WITH ANTI-TUMOUR ACTIVITY ELI LILLY AND COMPANY (US) 1989-11-29 EP claimed
EP-0222475-A1 Sulfonyl ureas with anti-tumour activity ELI LILLY AND COMPANY (US) 1987-05-20 EP claimed
CN-86106428-A Anti-tumor method and compound thereof 1987-03-18 CN claimed