Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA1 | Q09470 | 6/20 | 0.56 |
| ▸ | KCNAB1 | Q14722 | 6/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | CA9 | Q16790 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulofenur SCHEMBL29359159 | 0.88 | KCNA1 (0.65) | KCNA1KCNAB1CA2CA9CA12 | |
| Sulofenur SCHEMBL4174 | 0.88 | KCNA1 (0.65) | KCNA1KCNAB1CA2CA9CA12 | |
| SCHEMBL8878995 | 0.85 | KCNA1 (0.65) | KCNA1KCNAB1CA2CA9CA12 | |
| SCHEMBL13355422 | 0.83 | RAB9A (0.70) | CA2CA9CA12CA1RAB9A | |
| SCHEMBL28766991 | 0.82 | NPC1 (0.67) | KCNA1KCNAB1CA2CA9CA12 | |
| SCHEMBL15865553 | 0.82 | RAB9A (0.67) | KCNA1KCNAB1CA2CA9CA12 | |
| Ly-295501 SCHEMBL30351 | 0.81 | PKM (0.58) | KCNA1KCNAB1CA2CA9CA12 | |
| Ly-295501 SCHEMBL29375534 | 0.81 | PKM (0.58) | KCNA1KCNAB1CA2CA9CA12 | |
| SCHEMBL8761148 | 0.81 | PKM (0.51) | KCNA1KCNAB1CA2CA9CA1 | |
| SCHEMBL9486556 | 0.80 | MEN1 (0.67) | KCNA1KCNAB1CA2CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5594028-A | SULFONYLUREAS | ELI LILLY AND COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| US-5116874-A | Aminocarbonyl sulfonamide derivatives | ELI LILLY AND COMPANY (US) | 1992-05-26 | — | — | US | disclosed |
| EP-0222475-B1 | SULFONYL UREAS WITH ANTI-TUMOUR ACTIVITY | ELI LILLY AND COMPANY (US) | 1989-11-29 | — | — | EP | disclosed |
| EP-0222475-A1 | Sulfonyl ureas with anti-tumour activity | ELI LILLY AND COMPANY (US) | 1987-05-20 | — | — | EP | disclosed |