Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.64 |
| ▸ | NPC1 | O15118 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.64 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.64 |
| ▸ | MITF | O75030 | 1/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | XBP1 | P17861 | 1/20 | 0.64 |
| ▸ | NPBWR1 | P48145 | 6/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.60 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13967303 | 0.85 | NPBWR1 (0.58) | RAB9ANPC1ALDH1A1SMN1; SMN2PAX8 | |
| SCHEMBL11277555 | 0.84 | NPBWR1 (0.60) | RAB9ANPC1ALDH1A1SMN1; SMN2PAX8 | |
| SCHEMBL4675674 | 0.84 | RAB9A (0.64) | RAB9ANPC1ALDH1A1SMN1; SMN2PAX8 | |
| SCHEMBL3037242 | 0.82 | NPC1 (0.64) | RAB9ANPC1ALDH1A1SMN1; SMN2PAX8 | |
| SCHEMBL4670658 | 0.82 | RAB9A (0.70) | RAB9ANPC1ALDH1A1SMN1; SMN2PAX8 | |
| SCHEMBL4672474 | 0.82 | RAB9A (0.74) | RAB9ANPC1ALDH1A1SMN1; SMN2PAX8 | |
| SCHEMBL9831465 | 0.81 | RAB9A (0.71) | RAB9ANPC1ALDH1A1SMN1; SMN2PAX8 | |
| SCHEMBL10771272 | 0.81 | ACHE (0.48) | RAB9ANPC1ALDH1A1SMN1; SMN2PAX8 | |
| SCHEMBL11735456 | 0.81 | NPC1 (0.55) | RAB9ANPC1ALDH1A1SMN1; SMN2PAX8 | |
| SCHEMBL11732428 | 0.81 | RAB9A (0.48) | RAB9ANPC1ALDH1A1SMN1; SMN2PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9562019-B2 | Substituted pyridazines as EGFR and/or KRAS inhibitors | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2017-02-07 | — | — | US | disclosed |
| US-9562019-B2 | Substituted pyridazines as EGFR and/or KRAS inhibitors | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2017-02-07 | — | — | US | disclosed |
| EP-2518063-B1 | Pyridazinones and furan-containing compounds | SLOAN-KETTERING INST FOR CANCER RES (US) | 2017-02-01 | — | — | EP | disclosed |
| EP-2099770-B1 | PYRIDAZINONES AND FURAN-CONTAINING COMPOUNDS | SLOAN KETTERING INST CANCER (US) | 2015-06-10 | — | — | EP | disclosed |
| US-20130131062-A1 | PYRIDAZINONES AND FURAN-CONTAINING COMPOUNDS | DJABALLAH HAKIM (US) | 2013-05-23 | — | — | US | disclosed |
| US-20130131062-A1 | PYRIDAZINONES AND FURAN-CONTAINING COMPOUNDS | DJABALLAH HAKIM (US) | 2013-05-23 | — | — | US | disclosed |
| EP-2518063-A1 | Pyridazinones and furan-containing compounds | Sloan-Kettering Institute For Cancer Research (US) | 2012-10-31 | — | — | EP | disclosed |
| US-20100210649-A1 | PYRIDAZINONES AND FURAN-CONTAINING COMPOUNDS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2010-08-19 | — | — | US | disclosed |
| US-20100210649-A1 | PYRIDAZINONES AND FURAN-CONTAINING COMPOUNDS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2010-08-19 | — | — | US | disclosed |
| US-20090012088-A1 | Compounds for the Treatment of Neurodegeneration and Stroke | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2009-01-08 | — | — | US | disclosed |
| US-20090012088-A1 | Compounds for the Treatment of Neurodegeneration and Stroke | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2009-01-08 | — | — | US | disclosed |
| US-20090012088-A1 | Compounds for the Treatment of Neurodegeneration and Stroke | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2009-01-08 | — | — | US | disclosed |
| WO-2008080056-A2 | PYRIDAZINONES AND FURAN-CONTAINING COMPOUNDS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2008-07-03 | — | — | WO | disclosed |
| US-20070032496-A1 | Compounds for the Treatment of Neurodegeneration and Stroke | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2007-02-08 | — | — | US | disclosed |
| US-20070032496-A1 | Compounds for the Treatment of Neurodegeneration and Stroke | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2007-02-08 | — | — | US | disclosed |
| US-20070032496-A1 | Compounds for the Treatment of Neurodegeneration and Stroke | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2007-02-08 | — | — | US | disclosed |
| EP-0210647-B1 | PYRIDAZINONE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND INSECTICIDAL COMPOSITIONS | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1992-10-28 | — | — | EP | disclosed |
| US-4910201-A | With an ether substituted in position 5 | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1990-03-20 | — | — | US | disclosed |
| EP-0210647-A2 | Pyridazinone derivatives, process for preparation thereof and insecticidal compositions | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1987-02-04 | — | — | EP | disclosed |
| US-4002751-A | SLEEP INDUCERS, CNS DEPRESSANTS | SANDOZ, INC. (US) | 1977-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131062-A1 | PYRIDAZINONES AND FURAN-CONTAINING COMPOUNDS | DPYD, PDXK, TYMP | RAB9A 3655/4885NPC1 2857/4885ALDH1A1 761/4885 |
| US-20070032496-A1 | Compounds for the Treatment of Neurodegeneration and Stroke | PARP1, PARP12, PARP11 | RAB9A 2534/4885NPC1 996/4885ALDH1A1 1519/4885 |
| US-20100210649-A1 | PYRIDAZINONES AND FURAN-CONTAINING COMPOUNDS | DPYD, PDXK, TYMP | RAB9A 3655/4885NPC1 2857/4885ALDH1A1 761/4885 |
| US-20090012088-A1 | Compounds for the Treatment of Neurodegeneration and Stroke | PARP1, PARP12, PARP11 | RAB9A 2534/4885NPC1 996/4885ALDH1A1 1519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.