Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2091236 | 0.83 | SMN1; SMN2 (0.68) | ALDH1A1GAASMN1; SMN2RAB9AMAPT | |
| SCHEMBL18550663 | 0.80 | ALDH1A1 (0.61) | ALDH1A1GAASMN1; SMN2KDM4EMAPT | |
| SCHEMBL2254530 | 0.79 | ALDH1A1 (0.63) | ALDH1A1RAB9ANPSR1ALOX12KDM4E | |
| SCHEMBL2091233 | 0.78 | SMN1; SMN2 (0.61) | ALDH1A1GAASMN1; SMN2RAB9AMAPT | |
| SCHEMBL30002532 | 0.78 | SMN1; SMN2 (0.61) | ALDH1A1GAASMN1; SMN2RAB9AKDM4E | |
| SCHEMBL863826 | 0.78 | SMN1; SMN2 (0.61) | ALDH1A1GAASMN1; SMN2RAB9AKDM4E | |
| SCHEMBL4304855 | 0.76 | SMN1; SMN2 (0.59) | ALDH1A1GAASMN1; SMN2RAB9AKDM4E | |
| SCHEMBL9331432 | 0.75 | SMN1; SMN2 (0.59) | ALDH1A1GAASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2091871 | 0.75 | SMN1; SMN2 (0.58) | ALDH1A1GAASMN1; SMN2RAB9ANPSR1 | |
| SCHEMBL11761177 | 0.75 | HDAC3 (0.56) | ALDH1A1RAB9ANPSR1ALOX12KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090004185-A1 | AMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF BETA-CATENIN/TCF-4 PATHWAY AND CANCER TREATMENT AGENTS | WYETH (US) | 2009-01-01 | — | — | US | disclosed |
| WO-2008086462-A2 | AMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF β-CANTENIN/TCF-4 PATHWAY AND CANCER TREATMENT AGENTS | WYETH (US) | 2008-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090004185-A1 | AMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF BETA-CATENIN/TCF-4 PATHWAY AND CANCER TREATMENT AGENTS | TCF4, CTNNB1, TCF7 | ALDH1A1 2808/4885GAA 3406/4885SMN1; SMN2 4786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.