Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 3/20 | 0.42 |
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SPR | P35270 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4177020 | 0.94 | TRPC3 (0.51) | TRPC3TRPC6ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL4306708 | 0.94 | TRPC3 (0.44) | TRPC3TRPC6ALDH1A1SPRCYP2C9 | |
| SCHEMBL4184017 | 0.90 | KAT6A (0.42) | TRPC3TRPC6KDM4EGAAMAPT | |
| SCHEMBL4173605 | 0.86 | NPC1 (0.41) | TRPC3TRPC6ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4181072 | 0.86 | TRPV4 (0.40) | TRPC3TRPC6CRHBPCRHR2KAT6A | |
| SCHEMBL4176042 | 0.85 | ALDH1A1 (0.47) | TRPC3TRPC6ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4165262 | 0.84 | ALDH1A1 (0.41) | TRPC3TRPC6ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4176347 | 0.83 | ALDH1A1 (0.43) | TRPC3TRPC6ALDH1A1NPC1RAB9A | |
| SCHEMBL4176180 | 0.83 | ALDH1A1 (0.43) | TRPC3TRPC6ALDH1A1NPC1RAB9A | |
| SCHEMBL4321539 | 0.83 | TRPC3 (0.47) | TRPC3TRPC6ALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8357711-B2 | Heterocyclic sulfonamides as inhibitors of ion channels | PFIZER LIMITED (GB) | 2013-01-22 | — | — | US | disclosed |
| US-20090143358-A1 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (US) | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143358-A1 | INHIBITORS OF ION CHANNELS | TRPV1, TRPV5, TRPA1 | TRPC3 57/4885TRPC6 84/4885ALDH1A1 3113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.