Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TRPC3 | Q13507 | 6/20 | 0.42 |
| ▸ | TRPC6 | Q9Y210 | 6/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.38 |
| ▸ | RBP4 | P02753 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4176347 | 1.00 | ALDH1A1 (0.43) | ALDH1A1CYP2C9CYP2C19TRPC3TRPC6 | |
| SCHEMBL4321539 | 0.90 | TRPC3 (0.47) | ALDH1A1TRPC3TRPC6EPHX2HTR1A | |
| SCHEMBL4178536 | 0.83 | TRPC3 (0.42) | ALDH1A1CYP2C9CYP2C19TRPC3TRPC6 | |
| SCHEMBL4306708 | 0.83 | TRPC3 (0.44) | ALDH1A1CYP2C9CYP2C19TRPC3TRPC6 | |
| SCHEMBL4177020 | 0.81 | TRPC3 (0.51) | ALDH1A1TRPC3TRPC6KMT2AMEN1 | |
| SCHEMBL4178167 | 0.80 | TRPC3 (0.54) | ALDH1A1TRPC3TRPC6KDM5ANPC1 | |
| SCHEMBL3154330 | 0.79 | SCN8A (0.53) | SCN1ASCN8A | |
| SCHEMBL3169341 | 0.79 | SCN8A (0.53) | SCN1ASCN8A | |
| SCHEMBL4167596 | 0.78 | TRPC3 (0.44) | ALDH1A1CYP2C9CYP2C19TRPC3TRPC6 | |
| SCHEMBL4173605 | 0.77 | NPC1 (0.41) | ALDH1A1CYP2C9CYP2C19TRPC3TRPC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8357711-B2 | Heterocyclic sulfonamides as inhibitors of ion channels | PFIZER LIMITED (GB) | 2013-01-22 | — | — | US | disclosed |
| US-20090143358-A1 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (US) | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143358-A1 | INHIBITORS OF ION CHANNELS | TRPV1, TRPV5, TRPA1 | ALDH1A1 3113/4885CYP2C9 1382/4885CYP2C19 1818/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.