Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | CD44 | P16070 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27517559 | 0.82 | MEN1 (0.49) | DRD2DRD3ENPP2HRH1HTR2B | |
| SCHEMBL7478369 | 0.80 | GRIN1 (0.41) | DRD4DRD2ADRA2AGRIN1GRIN2B | |
| SCHEMBL2838994 | 0.80 | ALOX15 (0.51) | DHFRDRD4DRD2DRD3CD44 | |
| SCHEMBL6970695 | 0.77 | DRD4 (0.46) | DHFRDRD4DRD2DRD3CD44 | |
| SCHEMBL4185736 | 0.75 | CD44 (0.40) | DHFRDRD4DRD2DRD3CD44 | |
| SCHEMBL6967728 | 0.74 | CD44 (0.39) | DHFRDRD4DRD2DRD3CD44 | |
| SCHEMBL6964464 | 0.73 | DRD2 (0.56) | DRD4DRD2DRD3KDM4EALDH1A1 | |
| SCHEMBL6972430 | 0.73 | DRD2 (0.53) | DHFRDRD4DRD2DRD3ADRA2A | |
| SCHEMBL6957984 | 0.73 | DRD2 (0.56) | DHFRDRD4DRD2DRD3KDM4E | |
| SCHEMBL6973388 | 0.72 | TMEM97 (0.60) | DHFRDRD4DRD2DRD3ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008072061-A1 | METHOD OF TREATMENT OF OBESITY WITH AN MTP INHIBITOR IN CONJUNCTION WITH AN INCREASED-FAT DIET | PFIZER PRODUCTS INC. (US) | 2008-06-19 | — | — | WO | claimed |
| US-20090209492-A1 | Lipase Inhibitors | TRUSTEES OF TUFTS COLLEGE (US) | 2009-08-20 | — | — | US | disclosed |
| WO-2008072061-A1 | METHOD OF TREATMENT OF OBESITY WITH AN MTP INHIBITOR IN CONJUNCTION WITH AN INCREASED-FAT DIET | PFIZER PRODUCTS INC. (US) | 2008-06-19 | — | — | WO | disclosed |
| EP-1824861-A2 | LIPASE INHIBITORS | Trustees of the Tufts College (US) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006053250-A2 | LIPASE INHIBITORS | TRUSTEES OF TUFTS COLLEGE (US) | 2006-05-18 | — | — | WO | disclosed |
| EP-0902785-B1 | PROCESSES AND INTERMEDIATES FOR PREPARING 4'-TRIFLUOROMETHYLBIPHENYL-2-CARBOXYLIC ACID 2-(2H- 1,2,4]TRIAZOL-3-YLMETHYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-YL]-AMIDE | PFIZER (US) | 2002-09-04 | — | — | EP | disclosed |
| US-5998623-A | Process and intermediates for preparing 4'-trifluoromethylbiphenyl-2-carboxylic acid [2-(2H-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl]-a mide | PFIZER INC. (US) | 1999-12-07 | — | — | US | disclosed |
| CN-1216988-A | Process and intermediates for preparing 4-trifluoromethyl-biphenyl-2-carboxylic acid [2-(2H-[1,2,4] triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl]-amide | PFRIZER INC (US) | 1999-05-19 | — | — | CN | disclosed |
| EP-0902785-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING 4'-TRIFLUOROMETHYLBIPHENYL-2-CARBOXYLIC ACID 2-(2H- 1,2,4]TRIAZOL-3-YLMETHYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-YL]-AMIDE | PFIZER INC. (US) | 1999-03-24 | — | — | EP | disclosed |
| WO-1997041111-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING 4'-TRIFLUOROMETHYLBIPHENYL-2-CARBOXYLIC ACID [2-(2H-[1,2,4]TRIAZOL-3-YLMETHYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-YL]-AMIDE | PFIZER INC. (US) | 1997-11-06 | — | — | WO | disclosed |
| WO-1997041111-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING 4'-TRIFLUOROMETHYLBIPHENYL-2-CARBOXYLIC ACID [2-(2H-[1,2,4]TRIAZOL-3-YLMETHYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-YL]-AMIDE | PFIZER INC. (US) | 1997-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209492-A1 | Lipase Inhibitors | LIPG, LPL, PNLIP | DHFR 3318/4885DRD4 4498/4885DRD2 4375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.