Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Fluoride. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluoride SCHEMBL137553 | 1.00 | — | — | |
| Fluoride SCHEMBL3438899 | 1.00 | — | — | |
| Fluoride SCHEMBL10976257 | 1.00 | — | — | |
| Fluoride SCHEMBL3438898 | 1.00 | — | — | |
| Fluoride SCHEMBL477834 | 1.00 | — | — | |
| Fluoride SCHEMBL28569461 | 1.00 | — | — | |
| Fluoride SCHEMBL4973039 | 1.00 | — | — | |
| Fluoride SCHEMBL28535902 | 0.87 | — | — | |
| Methane SCHEMBL27412510 | 0.87 | — | — | |
| Fluoride SCHEMBL10930443 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108440687-A | The preparation method of alkyl xylan | 北京林业大学 | 2018-08-24 | — | — | CN | claimed |
| CN-106279543-B | A kind of preparation method of cellulose base hydrophobic material | 福建农林大学 | 2018-07-10 | — | — | CN | claimed |
| CN-107235952-B | A kind of synthetic method for helping peace moldin skeleton | 华东师范大学 | 2018-06-29 | — | — | CN | claimed |
| CN-107235952-A | It is a kind of to help the synthetic method for pacifying moldin skeleton | 华东师范大学 | 2017-10-10 | — | — | CN | claimed |
| CN-102675049-B | Axially chiral alpha-allene alcohol with optical activity, and synthesis method and application thereof | SHANGHAI INST ORGANIC CHEM | 2014-02-19 | — | — | CN | claimed |
| CN-102675049-A | Axially chiral alpha-allene alcohol with optical activity, and synthesis method and application thereof | SHANGHAI INST ORGANIC CHEM | 2012-09-19 | — | — | CN | claimed |
| CN-110191884-A | Substituted 6- (1H-pyrazol-1-yl) pyrimidine-4-amine derivatives and uses thereof | 拜耳公司 | 2019-08-30 | — | — | CN | disclosed |
| EP-3515915-A2 | PROCESS FOR PREPARING BETA-LACTAMASE INHIBITOR HYDROXYLUREA INTERMEDIATES | Merck Sharp & Dohme Corp. (US) | 2019-07-31 | — | — | EP | disclosed |
| US-10351504-B1 | Synthesis of hydroxyfluorene-carboxilic acid and esters thereof | MANDAVA NAGA BHUSHAN (US) | 2019-07-16 | — | — | US | disclosed |
| CN-109224082-A | A kind of macromolecular prodrug Nano medication, preparation method and applications | 东南大学 | 2019-01-18 | — | — | CN | disclosed |
| CN-106008302-B | A kind of vitamin D2The preparation method of derivative | 无锡贝塔医药科技有限公司 | 2018-08-07 | — | — | CN | disclosed |
| CN-107235952-B | A kind of synthetic method for helping peace moldin skeleton | 华东师范大学 | 2018-06-29 | — | — | CN | disclosed |
| CN-105358552-B | aryl-quinazoline | 默克专利股份公司 | 2018-04-27 | — | — | CN | disclosed |
| CN-1196720-A | Novel vitamin D analogues | LEO PHARM PROD LTD (DK) | 1998-10-21 | — | — | CN | disclosed |
| CN-1046892-A | FLUORINATED ARACHIDONIC ACID DERIVATIVES | MERRELL DOW PHARMA (US) | 1990-11-14 | — | — | CN | disclosed |
| EP-0352909-A2 | Monic acid derivatives | BEECHAM GROUP PLC (GB) | 1990-01-31 | — | — | EP | disclosed |
| EP-0327500-A2 | 5-Substituted 1H-pyrazolo[3,4-b]pyridine derivatives, their preparation and pharmaceutical compositions containing them | SANDOZ AG (CH) | 1989-08-09 | — | — | EP | disclosed |
| EP-0318090-A2 | Tert-butyl phenyl compounds as anti-inflammatory agents | THE PROCTER & GAMBLE COMPANY (US) | 1989-05-31 | — | — | EP | disclosed |
| EP-0291212-A1 | Polymerization of acrylic esters | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1988-11-17 | — | — | EP | disclosed |
| EP-0251408-A1 | Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation | THE PROCTER & GAMBLE COMPANY (US) | 1988-01-07 | — | — | EP | disclosed |