Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMKLR1 | Q99788 | 2/20 | 0.36 |
| ▸ | SYK | P43405 | 3/20 | 0.33 |
| ▸ | FLT3 | P36888 | 2/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | PDE9A | O76083 | 3/20 | 0.31 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4094452 | 0.90 | CMKLR1 (0.37) | CMKLR1SYKFLT3AURKBRXRA | |
| SCHEMBL4089146 | 0.90 | CMKLR1 (0.37) | CMKLR1SYKFLT3AURKBRXRA | |
| SCHEMBL4080214 | 0.86 | SCN9A (0.35) | CMKLR1SYKFLT3AURKBRXRA | |
| SCHEMBL4088673 | 0.84 | CMKLR1 (0.37) | CMKLR1RXRARXRBRXRGPTGDR2 | |
| SCHEMBL4094652 | 0.83 | RAB9A (0.37) | CMKLR1RXRARXRBRXRGATR | |
| SCHEMBL4079783 | 0.82 | CMKLR1 (0.36) | CMKLR1RXRARXRBRXRGATR | |
| SCHEMBL5381479 | 0.81 | CMKLR1 (0.34) | CMKLR1SYKFLT3AURKBPTGDR2 | |
| SCHEMBL4089935 | 0.81 | CMKLR1 (0.40) | CMKLR1RXRARXRBRXRGPTGDR2 | |
| SCHEMBL4080029 | 0.80 | CMKLR1 (0.35) | CMKLR1RXRARXRBRXRGATR | |
| SCHEMBL5378043 | 0.80 | RXRA (0.38) | CMKLR1RXRARXRBRXRGATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099178-A1 | INDAZOLE COMPOUNDS AND METHODS OF USE THEREOF | BHAGWAT SHRIPAD S | 2009-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099178-A1 | INDAZOLE COMPOUNDS AND METHODS OF USE THEREOF | WNT3, WNT3A, WNK3 | CMKLR1 1073/4885SYK 375/4885FLT3 1140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.