Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.71 |
| ▸ | NPC1 | O15118 | 4/20 | 0.71 |
| ▸ | TDP2 | O95551 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | RAB9A | P51151 | 3/20 | 0.71 |
| ▸ | NSD2 | O96028 | 2/20 | 0.71 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | THRB | P10828 | 1/20 | 0.71 |
| ▸ | XBP1 | P17861 | 1/20 | 0.71 |
| ▸ | GALK1 | P51570 | 1/20 | 0.71 |
| ▸ | BLM | P54132 | 1/20 | 0.71 |
| ▸ | ATM | Q13315 | 1/20 | 0.71 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4190274 | 0.72 | LMNA (0.68) | MAPTSMN1; SMN2NPC1TDP2LMNA | |
| SCHEMBL28229224 | 0.69 | TSHR (0.77) | SMN1; SMN2LMNAMEN1KMT2ATDP1 | |
| SCHEMBL3500556 | 0.68 | TSHR (0.81) | SMN1; SMN2LMNAMEN1KMT2ATDP1 | |
| SCHEMBL28583046 | 0.68 | LMNA (0.62) | MAPTSMN1; SMN2NPC1LMNARAB9A | |
| SCHEMBL11220189 | 0.68 | L3MBTL1 (0.52) | MAPTSMN1; SMN2NPC1LMNARAB9A | |
| SCHEMBL28278039 | 0.67 | SCN1A (0.61) | SMN1; SMN2LMNATDP1POLBTSHR | |
| SCHEMBL4196714 | 0.67 | SMN1; SMN2 (0.67) | MAPTSMN1; SMN2NPC1TDP2LMNA | |
| Anthraquinone SCHEMBL28110119 | 0.66 | ELANE (0.64) | SMN1; SMN2LMNAMEN1KMT2ATDP1 | |
| SCHEMBL4196351 | 0.66 | TDP2 (0.55) | MAPTSMN1; SMN2TDP2LMNANSD2 | |
| SCHEMBL5154230 | 0.66 | TSHR (0.65) | MAPTLMNATHRBATMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090036441-A1 | Indole Derivatives With Antitumor Activity | CELL THERAPEUTICS EUROPE S.R.L. (IT) | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036441-A1 | Indole Derivatives With Antitumor Activity | IDO1, IDO2, INMT | MAPT 2732/4885SMN1; SMN2 4350/4885NPC1 2846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.