Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 2/20 | 0.36 |
| ▸ | METAP1 | P53582 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.33 |
| ▸ | TCF7L2 | Q9NQB0 | 2/20 | 0.33 |
| ▸ | USP1 | O94782 | 1/20 | 0.33 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.33 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4178985 | 0.89 | GBA1 (0.39) | KDM4EHIF1APOLBGRIN1GRIN2B | |
| SCHEMBL4183377 | 0.89 | POLB (0.35) | CYP2C19CYP2D6METAP2METAP1KDM4E | |
| SCHEMBL4183066 | 0.88 | CYP3A4 (0.39) | CYP2C19CYP2D6KDM4EHIF1APOLB | |
| SCHEMBL4179058 | 0.87 | GBA1 (0.40) | METAP2METAP1HIF1AGRIN1GRIN2B | |
| SCHEMBL4185956 | 0.84 | POLB (0.35) | CYP2C19CYP2D6CYP2C9KDM4EHIF1A | |
| SCHEMBL4184002 | 0.84 | GBA1 (0.43) | CYP2D6HIF1AGRIN1GRIN2BGBA1 | |
| SCHEMBL4185582 | 0.84 | GBA1 (0.39) | HIF1AGRIN1GRIN2BGBA1PGK1 | |
| SCHEMBL4176452 | 0.80 | PGK1 (0.42) | KDM4EHIF1AGRIN1GRIN2BGBA1 | |
| SCHEMBL4179062 | 0.80 | KDM4E (0.43) | METAP2METAP1KDM4EGRIN1GRIN2B | |
| SCHEMBL13743133 | 0.79 | KDM4E (0.46) | KDM4EVNN1F2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090198057-A1 | Certain Chemical Entities, Compositions, and Methods | CYTOKINETICS, INCORPORATED | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090198057-A1 | Certain Chemical Entities, Compositions, and Methods | MYLK, MYH2, MYH10 | CYP2C19 2307/4885CYP2D6 2173/4885CYP2C9 3010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.