Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | STS | P08842 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4185542 | 1.00 | ALDH1A1 (0.39) | ALDH1A1GPR119PTGS2STSSMN1; SMN2 | |
| SCHEMBL4190114 | 0.88 | ALDH1A1 (0.43) | ALDH1A1PTGS2SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL4190117 | 0.88 | ALDH1A1 (0.43) | ALDH1A1PTGS2SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL4190120 | 0.88 | ALDH1A1 (0.43) | ALDH1A1PTGS2SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL13927876 | 0.86 | LMNA (0.44) | ALDH1A1PTGS2SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL13927920 | 0.83 | PTGS2 (0.40) | ALDH1A1PTGS2SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL25368200 | 0.83 | STS (0.42) | ALDH1A1GPR119STSSMN1; SMN2KMT2A | |
| SCHEMBL4187138 | 0.82 | ALDH1A1 (0.43) | ALDH1A1GPR119NPC1RAB9AMAPT | |
| SCHEMBL4187142 | 0.82 | ALDH1A1 (0.43) | ALDH1A1GPR119NPC1RAB9AMAPT | |
| SCHEMBL5362064 | 0.81 | ALDH1A1 (0.50) | ALDH1A1GPR119STSSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090042874-A1 | ANTIDEPRESSANT HETEROARYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | WYETH (US) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042874-A1 | ANTIDEPRESSANT HETEROARYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | HTR5A, CRH, CYP17A1 | ALDH1A1 643/4885GPR119 100/4885PTGS2 3128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.