SCHEMBL4186012

SCHEMBL4186012

Cc1noc(C)c1-c1ccc(S(=O)(=O)Nc2ccccc2CNC(C)CC2CCCCC2)s1

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.38
PKM P14618 1/20 0.38
POLB P06746 2/20 0.38
NPC1 O15118 2/20 0.38
RAB9A P51151 1/20 0.38
RORC P51449 1/20 0.38
EDNRB P24530 1/20 0.37
EDNRA P25101 1/20 0.37
MAPT P10636 4/20 0.37
TP53 P04637 2/20 0.37
BRD4 O60885 8/20 0.34
BRD2 P25440 6/20 0.34
BRD3 Q15059 6/20 0.34
NR3C2 P08235 1/20 0.34
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4201621 1.00 KDM4E (0.38) KDM4EPKMPOLBNPC1RAB9A
SCHEMBL4203956 0.99 POLB (0.38) KDM4EPKMPOLBNPC1RAB9A
SCHEMBL4195595 0.85 KMT2A (0.41) KDM4EPKMPOLBNPC1RAB9A
SCHEMBL4184130 0.85 KMT2A (0.41) KDM4EPKMPOLBNPC1RAB9A
SCHEMBL4198365 0.84 ALDH1A1 (0.48) KDM4EPKMPOLBMAPTNR3C2
SCHEMBL4185970 0.84 KDM4E (0.40) KDM4EPKMPOLBEDNRBEDNRA
SCHEMBL4195547 0.84 KMT2A (0.42) KDM4EPKMPOLBNPC1RAB9A
SCHEMBL4191048 0.84 KDM4E (0.48) KDM4EPKMPOLBTP53BRD4
SCHEMBL4706508 0.84 KDM4E (0.40) KDM4EPKMPOLBNPC1RAB9A
SCHEMBL4197564 0.83 KDM4E (0.39) KDM4EPKMPOLBEDNRBEDNRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1879877-B1 ANTIMICROBIAL AGENTS RANBAXY LAB LTD (IN) 2013-01-02 EP claimed
US-8076370-B2 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2011-12-13 US claimed
US-20090215764-A1 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2009-08-27 US claimed
EP-1879877-B1 ANTIMICROBIAL AGENTS RANBAXY LAB LTD (IN) 2013-01-02 EP disclosed
US-8076370-B2 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2011-12-13 US disclosed
US-20090215764-A1 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2009-08-27 US disclosed
EP-1879877-A2 ANTIMICROBIAL AGENTS Ranbaxy Laboratories Limited (IN) 2008-01-23 EP disclosed
WO-2006117762-A2 ANTIMICROBIAL AGENTS RANBAXY LABORATORIES LIMITED (IN) 2006-11-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090215764-A1 Antimicrobial agents TUFM, RPS17, HARS1 KDM4E 3328/4885PKM 1855/4885POLB 215/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.