Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18485398 | 0.87 | CES1 (0.47) | DNMT1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL18485380 | 0.82 | CES1 (0.50) | DNMT1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL18485438 | 0.81 | DNMT1 (0.45) | DNMT1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL18485415 | 0.81 | KDM4E (0.45) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL18485428 | 0.78 | ALDH1A1 (0.43) | DNMT1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL18485437 | 0.78 | MAPT (0.43) | DNMT1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL18485424 | 0.78 | DNMT1 (0.41) | DNMT1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL12235635 | 0.76 | CYP1B1 (0.53) | DNMT1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL18485411 | 0.76 | KMT2A (0.43) | ALDH1A1KMT2ARAB9ASMN1; SMN2LMNA | |
| SCHEMBL18485422 | 0.76 | DNMT1 (0.46) | DNMT1ALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3902788-B1 | NAPHTHALIMIDE DERIVATIVES AS ANTI-PARASITIC AGENTS FOR THE TREATMENT OF LEISHMANIASIS AS WELL AS VIRAL, BACTERIAL AND NEOPLASTIC DISEASES | UNIV ISTANBUL MEDIPOL (TR) | 2024-02-21 | — | — | EP | claimed |
| US-20220143005-A1 | NAPHTHALIMIDE DERIVATIVES AS ANTI-PARASITIC AGENTS FOR THE TREATMENT OF LEISHMANIASIS AS WELL AS VIRAL, BACTERIAL AND NEOPLASTIC DISEASES | ISTANBUL MEDIPOL UNIVERSITESI (TR) | 2022-05-12 | — | — | US | claimed |
| EP-3902788-A1 | NAPHTHALIMIDE DERIVATIVES AS ANTI-PARASITIC AGENTS FOR THE TREATMENT OF LEISHMANIASIS AS WELL AS VIRAL, BACTERIAL AND NEOPLASTIC DISEASES | Istanbul Medipol Universitesi (TR) | 2021-11-03 | — | — | EP | claimed |
| WO-2020139291-A1 | NAPHTHALIMIDE DERIVATIVES AS ANTI-PARASITIC AGENTS FOR THE TREATMENT OF LEISHMANIASIS AS WELL AS VIRAL, BACTERIAL AND NEOPLASTIC DISEASES | ISTANBUL MEDIPOL UNIVERSITESI (TR) | 2020-07-02 | — | — | WO | claimed |
| EP-3902788-B1 | NAPHTHALIMIDE DERIVATIVES AS ANTI-PARASITIC AGENTS FOR THE TREATMENT OF LEISHMANIASIS AS WELL AS VIRAL, BACTERIAL AND NEOPLASTIC DISEASES | UNIV ISTANBUL MEDIPOL (TR) | 2024-02-21 | — | — | EP | disclosed |
| US-20220143005-A1 | NAPHTHALIMIDE DERIVATIVES AS ANTI-PARASITIC AGENTS FOR THE TREATMENT OF LEISHMANIASIS AS WELL AS VIRAL, BACTERIAL AND NEOPLASTIC DISEASES | ISTANBUL MEDIPOL UNIVERSITESI (TR) | 2022-05-12 | — | — | US | disclosed |
| EP-3902788-A1 | NAPHTHALIMIDE DERIVATIVES AS ANTI-PARASITIC AGENTS FOR THE TREATMENT OF LEISHMANIASIS AS WELL AS VIRAL, BACTERIAL AND NEOPLASTIC DISEASES | Istanbul Medipol Universitesi (TR) | 2021-11-03 | — | — | EP | disclosed |
| WO-2020139291-A1 | NAPHTHALIMIDE DERIVATIVES AS ANTI-PARASITIC AGENTS FOR THE TREATMENT OF LEISHMANIASIS AS WELL AS VIRAL, BACTERIAL AND NEOPLASTIC DISEASES | ISTANBUL MEDIPOL UNIVERSITESI (TR) | 2020-07-02 | — | — | WO | disclosed |
| WO-2018106200-A1 | ORIGINAL DRUG MOLECULES FOR THE TREATMENT OF PARASITIC AND NEOPLASTIC DISEASES AND METHODS FOR PREPARATION THEREOF | T.C MEDİPOL ÜNİVERSİTESİ (TR) | 2018-06-14 | — | — | WO | disclosed |
| WO-2016113763-A1 | A NOVEL ANTILEISHMANIAL FORMULATION | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-07-21 | — | — | WO | disclosed |
| EP-2029545-B1 | Bisnaphthalimidopropyl derivatives with anti-parasite and anti-cancer activity | UNIV DO PORTO (PT) | 2014-12-17 | — | — | EP | disclosed |
| EP-2029545-B1 | Bisnaphthalimidopropyl derivatives with anti-parasite and anti-cancer activity | UNIV DO PORTO (PT) | 2014-12-17 | — | — | EP | disclosed |
| US-20090062329-A1 | BISNAPHTHALIMIDOPROPYL DERIVATIVE COMPOUNDS WITH ANTI-PARASITE AND ANTI-CANCER ACTIVITY | UNIVERSIDADE DO PORTO (PT) | 2009-03-05 | — | — | US | disclosed |
| US-20090062329-A1 | BISNAPHTHALIMIDOPROPYL DERIVATIVE COMPOUNDS WITH ANTI-PARASITE AND ANTI-CANCER ACTIVITY | UNIVERSIDADE DO PORTO (PT) | 2009-03-05 | — | — | US | disclosed |
| EP-2029545-A2 | BISNAPHTHALIMIDOPROPYL DERIVATIVE COMPOUNDS WITH ANTI-PARASITE AND ANTI-CANCER ACTIVITY | Universidade Do Porto (PT) | 2009-03-04 | — | — | EP | disclosed |
| EP-2029545-A2 | BISNAPHTHALIMIDOPROPYL DERIVATIVE COMPOUNDS WITH ANTI-PARASITE AND ANTI-CANCER ACTIVITY | Universidade Do Porto (PT) | 2009-03-04 | — | — | EP | disclosed |
| WO-2008007262-B1 | BISNAPHTHALIMIDOPROPYL DERIVATIVE COMPOUNDS WITH ANTI-PARASITE AND ANTI-CANCER ACTIVITY | UNIV DO PORTO (PT) | 2008-10-09 | — | — | WO | disclosed |
| WO-2008007262-A3 | BISNAPHTHALIMIDOPROPYL DERIVATIVE COMPOUNDS WITH ANTI-PARASITE AND ANTI-CANCER ACTIVITY | UNIV DO PORTO (PT) | 2008-08-14 | — | — | WO | disclosed |
| WO-2008007262-A2 | BISNAPHTHALIMIDOPROPYL DERIVATIVE COMPOUNDS WITH ANTI-PARASITE AND ANTI-CANCER ACTIVITY | UNIVERSIDADE DO PORTO (PT) | 2008-01-17 | — | — | WO | disclosed |
| WO-2008007262-A2 | BISNAPHTHALIMIDOPROPYL DERIVATIVE COMPOUNDS WITH ANTI-PARASITE AND ANTI-CANCER ACTIVITY | UNIVERSIDADE DO PORTO (PT) | 2008-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220143005-A1 | NAPHTHALIMIDE DERIVATIVES AS ANTI-PARASITIC AGENTS FOR THE TREATMENT OF LEISHMANIASIS AS WELL AS VIRAL, BACTERIAL AND NEOPLASTIC DISEASES | NPM1, ECI1, IPO5 | DNMT1 976/4885ALDH1A1 785/4885MAPT 4360/4885 |
| US-20090062329-A1 | BISNAPHTHALIMIDOPROPYL DERIVATIVE COMPOUNDS WITH ANTI-PARASITE AND ANTI-CANCER ACTIVITY | DCPS, SI, MYADM | DNMT1 1643/4885ALDH1A1 3939/4885MAPT 4433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.