Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.76 |
| ▸ | THRB | P10828 | 1/20 | 0.76 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.76 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.68 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.68 |
| ▸ | ITGAV | P06756 | 1/20 | 0.68 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.68 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7309663 | 0.95 | THRB (0.70) | KMT2ATHRBALOX12ITGB3ITGB1 | |
| SCHEMBL16098798 | 0.91 | THRB (0.73) | KMT2ATHRBALOX12ITGB3ITGB1 | |
| SCHEMBL27627515 | 0.89 | ALDH1A1 (0.79) | KMT2ATHRBALOX12SMN1; SMN2NPC1 | |
| SCHEMBL5734401 | 0.88 | NPC1 (0.63) | KMT2ATHRBALOX12ITGB3ITGB1 | |
| Iodide SCHEMBL10827466 | 0.87 | NPC1 (0.62) | KMT2ATHRBALOX12ITGB3ITGB1 | |
| SCHEMBL5734080 | 0.87 | THRB (0.75) | KMT2ATHRBALOX12ITGB3ITGB1 | |
| SCHEMBL5850374 | 0.87 | KMT2A (0.75) | KMT2ATHRBALOX12ITGB3ITGB1 | |
| SCHEMBL20446598 | 0.87 | THRB (0.75) | KMT2ATHRBALOX12ITGB3ITGB1 | |
| SCHEMBL4190364 | 0.87 | THRB (0.75) | KMT2ATHRBALOX12ITGB3ITGB1 | |
| SCHEMBL23418057 | 0.85 | ALDH1A1 (0.70) | KMT2ATHRBALOX12SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117180269-A | Application of Intergrin alpha 4 beta 1 agonist in preparation of product for improving hematopoietic stem cell implantation success rate | 上海市第一人民医院 | 2023-12-08 | — | — | CN | claimed |
| CN-117180269-A | Application of Intergrin alpha 4 beta 1 agonist in preparation of product for improving hematopoietic stem cell implantation success rate | 上海市第一人民医院 | 2023-12-08 | — | — | CN | disclosed |
| EP-2051975-B1 | SUBSTITUTED PROLINAMIDES, PRODUCTION THEREOF AND THEIR USE AS DRUGS | BOEHRINGER INGELHEIM INT (DE) | 2012-09-12 | — | — | EP | disclosed |
| US-7504500-B2 | Method for the production of pyrrolidine-1,2-dicarboxylic acid-1-(phenyl(-amide))-2(phenyl(-amide)) derivatives and 1-(phenylcarbamoyl)-pyrrolidine-2-carboxylic acid derivatives as intermediate products | MERCK PATENT GMBH (DE) | 2009-03-17 | — | — | US | disclosed |
| EP-1760081-A1 | Method for the production of pyrrolidine-1,2-dicarboxylic acid-1-(phenyl(-amide))-2-(phenyl(-amide)) derivatives and 1-(phenylcarbamoyl)-pyrrolidine-2-carboxylic acid derivatives as intermediate products | Merck Patent GmbH (DE) | 2007-03-07 | — | — | EP | disclosed |
| US-20060211692-A1 | Method for the production of pyrrolidine-1,2-dicarboxylic acid-1-(phenyl(-amide))-2-(phenyl(-amide)) derivatives and 1-(phenylcarbamoyl)-pyrrolidine-2-carboxylic acid derivatives as intermediate products | MERCK PATENT GMBH (DE) | 2006-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211692-A1 | Method for the production of pyrrolidine-1,2-dicarboxylic acid-1-(phenyl(-amide))-2-(phenyl(-amide)) derivatives and 1-(phenylcarbamoyl)-pyrrolidine-2-carboxylic acid derivatives as intermediate products | PDHA2, PDHA1, CPS1 | KMT2A 1826/4885THRB 2811/4885ALOX12 2471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.