Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 8/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3584894 | 0.87 | RAB9A (0.80) | RAB9AALDH1A1MAPTLMNATP53 | |
| SCHEMBL4915021 | 0.82 | NPC1 (0.63) | RAB9AALDH1A1LMNATP53NPC1 | |
| SCHEMBL3588056 | 0.82 | NPC1 (0.63) | RAB9AALDH1A1MAPTLMNANPC1 | |
| SCHEMBL4189293 | 0.82 | PKM (0.76) | RAB9AALDH1A1MAPTLMNATP53 | |
| SCHEMBL4191961 | 0.81 | ALOX5 (0.57) | RAB9AALDH1A1MAPTLMNATP53 | |
| SCHEMBL4199045 | 0.80 | THRB (0.56) | RAB9AALDH1A1MAPTTP53NPC1 | |
| SCHEMBL4202722 | 0.80 | HPGD (0.61) | RAB9AALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL4188817 | 0.79 | RXFP1 (0.66) | RAB9AALDH1A1MAPTLMNATP53 | |
| SCHEMBL4197928 | 0.78 | NPC1 (0.67) | RAB9AALDH1A1MAPTLMNANPC1 | |
| SCHEMBL3582729 | 0.75 | NPC1 (0.73) | RAB9AALDH1A1MAPTLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029138-A1 | AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2009-03-04 | — | — | EP | claimed |
| WO-2007130075-A1 | AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2007-11-15 | — | — | WO | claimed |