Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | LCK | P06239 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4189264 | 0.90 | PKM (0.76) | PKMTDP1KDM4EMEN1KMT2A | |
| SCHEMBL3587905 | 0.87 | PKM (1.00) | PKMTDP1KDM4EMEN1KMT2A | |
| SCHEMBL4195677 | 0.83 | PKM (0.70) | PKMTDP1KDM4EMEN1KMT2A | |
| SCHEMBL4188732 | 0.82 | RAB9A (0.61) | PKMTDP1KDM4EMEN1KMT2A | |
| SCHEMBL3588056 | 0.80 | NPC1 (0.63) | PKMTDP1KDM4EMEN1KMT2A | |
| SCHEMBL4915021 | 0.80 | NPC1 (0.63) | PKMTDP1KDM4EMEN1KMT2A | |
| SCHEMBL4397896 | 0.79 | PKM (0.83) | PKMTDP1KDM4EMEN1KMT2A | |
| SCHEMBL4199045 | 0.78 | THRB (0.56) | KDM4EMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL3587473 | 0.76 | KDM4E (0.81) | PKMTDP1KDM4EMEN1KMT2A | |
| SCHEMBL4202722 | 0.76 | HPGD (0.61) | PKMKDM4EMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029138-A1 | AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2009-03-04 | — | — | EP | claimed |
| WO-2007130075-A1 | AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2007-11-15 | — | — | WO | claimed |