SCHEMBL4190907

SCHEMBL4190907

Cc1nc(C)c(S(=O)(=O)Nc2cccc(S(=O)(=O)Nc3ccccc3CN[C@@H](C)CC3CCCCC3)c2)s1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PKM P14618 2/20 0.40
KDM4E B2RXH2 1/20 0.40
ALDH1A1 P00352 5/20 0.37
HSD11B1 P28845 1/20 0.36
LMNA P02545 5/20 0.36
MAPT P10636 4/20 0.36
MAPK1 P28482 2/20 0.36
TP53 P04637 2/20 0.36
CTSD P07339 1/20 0.34
BACE1 P56817 1/20 0.34
BACE2 Q9Y5Z0 1/20 0.34
HTT P42858 4/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
XBP1 P17861 1/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
PI4KB Q9UBF8 4/20 0.33
HPGD P15428 1/20 0.33
KIT P10721 1/20 0.33
ALOX15 P16050 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4185944 0.91 PKM (0.46) PKMKDM4EALDH1A1LMNAMAPT
SCHEMBL4200078 0.91 PKM (0.42) PKMKDM4EALDH1A1LMNAMAPT
SCHEMBL4204307 0.91 PKM (0.42) PKMKDM4EALDH1A1LMNAMAPT
SCHEMBL4185875 0.90 PKM (0.41) PKMKDM4EALDH1A1HSD11B1LMNA
SCHEMBL4197554 0.87 KDM4E (0.39) PKMKDM4EALDH1A1LMNAMAPT
SCHEMBL4189913 0.84 KDM4E (0.45) PKMKDM4EALDH1A1LMNAMAPT
SCHEMBL4194882 0.83 KDM4E (0.41) PKMKDM4EALDH1A1LMNAMAPT
SCHEMBL4197769 0.83 ALDH1A1 (0.42) PKMKDM4EALDH1A1LMNAMAPT
SCHEMBL4200160 0.82 ACLY (0.39) PKMKDM4EALDH1A1LMNAMAPT
SCHEMBL4197992 0.82 MEN1 (0.42) PKMKDM4EALDH1A1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1879877-B1 ANTIMICROBIAL AGENTS RANBAXY LAB LTD (IN) 2013-01-02 EP claimed
US-8076370-B2 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2011-12-13 US claimed
US-20090215764-A1 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2009-08-27 US claimed
EP-1879877-B1 ANTIMICROBIAL AGENTS RANBAXY LAB LTD (IN) 2013-01-02 EP disclosed
US-8076370-B2 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2011-12-13 US disclosed
US-20090215764-A1 Antimicrobial agents RANBAXY LABORATORIES LIMITED (IN) 2009-08-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090215764-A1 Antimicrobial agents TUFM, RPS17, HARS1 PKM 1855/4885KDM4E 3328/4885ALDH1A1 2744/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.