Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | BCL2 | P10415 | 1/20 | 0.46 |
| ▸ | BAD | Q92934 | 1/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | LIPE | Q05469 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 3/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PREP | P48147 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20738530 | 1.00 | NOTUM (0.56) | NOTUMOPRM1OPRD1OPRK1HSD17B3 | |
| SCHEMBL20738534 | 1.00 | NOTUM (0.56) | NOTUMOPRM1OPRD1OPRK1HSD17B3 | |
| SCHEMBL15355395 | 0.86 | OPRM1 (0.49) | NOTUMOPRM1OPRD1OPRK1BCL2 | |
| SCHEMBL20738518 | 0.84 | NOTUM (0.54) | NOTUMOPRM1HSD17B3OPRL1KCNH2 | |
| SCHEMBL24925917 | 0.81 | OPRM1 (0.49) | NOTUMOPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL24925839 | 0.81 | OPRM1 (0.49) | NOTUMOPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL18970120 | 0.81 | LMNA (0.54) | NOTUMOPRM1OPRD1OPRK1BCL2 | |
| SCHEMBL24925818 | 0.81 | OPRM1 (0.49) | NOTUMOPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL1690525 | 0.81 | LMNA (0.54) | NOTUMOPRM1OPRD1OPRK1BCL2 | |
| SCHEMBL26818008 | 0.81 | OPRM1 (0.55) | NOTUMOPRM1OPRD1OPRK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230019032-A1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2023-01-19 | — | — | US | disclosed |
| US-11001575-B1 | Benzolactam compounds as protein kinase inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2021-05-11 | — | — | US | disclosed |
| EP-3330252-B1 | ISOPRENYL COMPOUNDS AND METHODS THEREOF | SIGNUM BIOSCIENCES INC (US) | 2020-02-12 | — | — | EP | disclosed |
| US-10457669-B2 | Benzolactam compounds as protein kinase inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2019-10-29 | — | — | US | disclosed |
| US-20190047990-A1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2019-02-14 | — | — | US | disclosed |
| US-9744147-B2 | Isoprenyl compounds and methods thereof | SIGNUM BIOSCIENCES, INC. (US) | 2017-08-29 | — | — | US | disclosed |
| US-20160361283-A1 | Isoprenyl Compounds and Methods Thereof | SIGNUM DERMALOGIX, INC. | 2016-12-15 | — | — | US | disclosed |
| US-9376383-B2 | Isoprenyl compounds | SIGNUM BIOSCIENCES, INC. (US) | 2016-06-28 | — | — | US | disclosed |
| EP-2616808-B1 | PROLYL ENDOPEPTIDASE PROBES | STANFORD RES INST INT (US) | 2015-02-25 | — | — | EP | disclosed |
| EP-2616808-B1 | PROLYL ENDOPEPTIDASE PROBES | STANFORD RES INST INT (US) | 2015-02-25 | — | — | EP | disclosed |
| WO-2012037044-A2 | PROLYL ENDOPEPTIDASE PROBES | SRI INTERNATIONAL (US) | 2012-03-22 | — | — | WO | disclosed |
| US-20120065103-A1 | Prolyl Endopeptidase Probes | SRI INTERNATIONAL | 2012-03-15 | — | — | US | disclosed |
| US-20120065103-A1 | Prolyl Endopeptidase Probes | SRI INTERNATIONAL | 2012-03-15 | — | — | US | disclosed |
| US-4228170-A | INHIBITOR OF PHENYLETHANOLAMINE N-METHYLTRANSFERASE | SMITHKLINE CORPORATION (US) | 1980-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065103-A1 | Prolyl Endopeptidase Probes | PREP, XPNPEP1, ANPEP | NOTUM 1014/4885OPRM1 2913/4885OPRD1 2513/4885 |
| US-20230019032-A1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | MAPK1, ALK, MAP3K1 | NOTUM 4102/4885OPRM1 571/4885OPRD1 1398/4885 |
| US-20160361283-A1 | Isoprenyl Compounds and Methods Thereof | ALOX15B, ALOX15, ALOX5 | NOTUM 10/4885OPRM1 4762/4885OPRD1 3514/4885 |
| US-20190047990-A1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | MAPK1, ALK, MAP3K1 | NOTUM 4102/4885OPRM1 571/4885OPRD1 1398/4885 |
| US-11001575-B1 | Benzolactam compounds as protein kinase inhibitors | MAPK1, ALK, MAP3K1 | NOTUM 4156/4885OPRM1 572/4885OPRD1 1370/4885 |
| US-10457669-B2 | Benzolactam compounds as protein kinase inhibitors | MAPK1, ALK, MAP3K1 | NOTUM 4102/4885OPRM1 571/4885OPRD1 1398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.