Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.53 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | BACE1 | P56817 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | MC4R | P32245 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634913 | 0.91 | CYP3A4 (0.47) | CYP3A4HSD17B10SIGMAR1OPRL1ACHE | |
| SCHEMBL22857018 | 0.83 | MC4R (0.44) | CYP3A4SIGMAR1ACHEMC4ROPRM1 | |
| SCHEMBL19641364 | 0.83 | CYP3A4 (0.57) | CYP3A4HSD17B10SIGMAR1OPRL1ACHE | |
| SCHEMBL27890446 | 0.82 | CYP3A4 (0.46) | CYP3A4SIGMAR1OPRL1MEN1KMT2A | |
| SCHEMBL21410719 | 0.82 | CYP3A4 (0.56) | CYP3A4HSD17B10SIGMAR1OPRL1ACHE | |
| SCHEMBL9744423 | 0.81 | NPFFR1 (0.56) | CYP3A4HSD17B10SIGMAR1OPRL1ACHE | |
| SCHEMBL20069007 | 0.79 | CYP2D6 (0.50) | SIGMAR1OPRL1ACHEALDH1A1MEN1 | |
| SCHEMBL12013906 | 0.79 | SIGMAR1 (0.65) | CYP3A4HSD17B10SIGMAR1OPRL1ACHE | |
| SCHEMBL11039283 | 0.79 | CYP3A4 (0.43) | CYP3A4OPRL1MEN1KMT2AOPRM1 | |
| SCHEMBL27800697 | 0.79 | CYP3A4 (0.43) | CYP3A4OPRL1TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090124635-A1 | CHEMICAL COMPOUNDS | PFIZER INC. (GB) | 2009-05-14 | — | — | US | disclosed |
| US-20090124635-A1 | CHEMICAL COMPOUNDS | PFIZER INC. (GB) | 2009-05-14 | — | — | US | disclosed |
| US-20090124635-A1 | CHEMICAL COMPOUNDS | PFIZER INC. (GB) | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124635-A1 | CHEMICAL COMPOUNDS | CCR5, CXCR3, CCR2 | CYP3A4 657/4885HSD17B10 2030/4885SIGMAR1 501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.