Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4192228 | 1.00 | CASP1 (0.41) | CASP1HCAR2ALDH1A1 | |
| SCHEMBL8593221 | 0.87 | CASP1 (0.44) | CASP1HCAR2ALDH1A1 | |
| SCHEMBL9084392 | 0.87 | CASP1 (0.44) | CASP1HCAR2ALDH1A1 | |
| SCHEMBL20223367 | 0.81 | CASP1 (0.41) | CASP1HCAR2ALDH1A1 | |
| SCHEMBL278041 | 0.80 | — | — | |
| SCHEMBL20589645 | 0.80 | — | — | |
| SCHEMBL932916 | 0.80 | — | — | |
| SCHEMBL18037713 | 0.79 | CASP1 (0.40) | CASP1HCAR2 | |
| SCHEMBL16371556 | 0.79 | CASP1 (0.40) | CASP1HCAR2 | |
| SCHEMBL10671631 | 0.78 | HCAR2 (0.48) | CASP1HCAR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114302886-B | Triazolopyridazine derivative, preparation method, pharmaceutical composition and application thereof | 上海赛默罗生物科技有限公司 | 2024-03-22 | — | — | CN | disclosed |
| US-20230136194-A1 | TRIAZOLOPYRIDAZINE DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | Shanghai Simr Biotechnology Co., Ltd. (CN) | 2023-05-04 | — | — | US | disclosed |
| EP-4017593-A1 | BICYCLIC AGONISTS OF STIMULATOR OF INTERFERON GENES STING | The Scripps Research Institute (US) | 2022-06-29 | — | — | EP | disclosed |
| US-11344637-B2 | Probes for imaging huntingtin protein | CHDI FOUNDATION, INC. (US) | 2022-05-31 | — | — | US | disclosed |
| EP-3340796-B1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION INC (US) | 2021-04-21 | — | — | EP | disclosed |
| US-20210060187-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2021-03-04 | — | — | US | disclosed |
| WO-2021035258-A1 | BICYCLIC AGONISTS OF STIMULATOR OF INTERFERON GENES STING | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-02-25 | — | — | WO | disclosed |
| CN-107531669-B | Pyridazine derivatives as RORc modulators | 豪夫迈·罗氏有限公司 | 2020-12-18 | — | — | CN | disclosed |
| US-10765764-B2 | Probes for imaging huntingtin protein | CHDI FOUNDATION, INC. (US) | 2020-09-08 | — | — | US | disclosed |
| US-20190167821-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2019-06-06 | — | — | US | disclosed |
| US-20150119390-A1 | IMIDAZOTHIADIAZOLE AND IMIDAZOPYRIDAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION | BRISTOL-MYERS SQUIBB COMPANY | 2015-04-30 | — | — | US | disclosed |
| US-20090137558-A1 | Pyridine based compounds useful as intermediates for pharmaceutical or agricultural end-products | PEAKDALE MOLECULAR LIMITED (GB) | 2009-05-28 | — | — | US | disclosed |
| EP-1824828-A2 | PYRIDINE BASED COMPOUNDS USEFUL AS INTERMEDIATES FOR PHARMACEUTICAL OR AGRICULTURAL END-PRODUCTS | Peakdale Molecular Limited (GB) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006059103-A2 | PYRIDINE BASED COMPOUNDS USEFUL AS INTERMEDIATES FOR PHARMACEUTICAL OR AGRICULTURAL END-PRODUCTS | PEAKDALE MOLECULAR LIMITED (GB) | 2006-06-08 | — | — | WO | disclosed |
| EP-0957097-B1 | Process for the preparation pf 3-isoxazolecarboxylic acid | SHIONOGI & CO (JP) | 2002-08-28 | — | — | EP | disclosed |
| EP-0739885-B1 | PROCESS FOR PRODUCING 3-ISOXAZOLECARBOXYLIC ACID | SHIONOGI & CO (JP) | 2000-04-19 | — | — | EP | disclosed |
| EP-0957097-A1 | Process for the preparation pf 3-isoxazolecarboxylic acid | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1999-11-17 | — | — | EP | disclosed |
| US-5760244-A | Process for the preparation of 3-isoxazolecarboxylic acid | SHIONOGI & CO., LTD. (JP) | 1998-06-02 | — | — | US | disclosed |
| US-5696271-A | Process for the preparation of 3-isoxazolecarboxylic acid | SHIONOGI & CO., LTD. (JP) | 1997-12-09 | — | — | US | disclosed |
| EP-0739885-A1 | PROCESS FOR PRODUCING 3-ISOXAZOLECARBOXYLIC ACID | SHIONOGI & CO., LTD. (JP) | 1996-10-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230136194-A1 | TRIAZOLOPYRIDAZINE DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | ABCG2, CYP4F8, CYP3A5 | CASP1 2182/4885HCAR2 1473/4885ALDH1A1 440/4885 |
| US-11344637-B2 | Probes for imaging huntingtin protein | HTT, HYPK, HSPBP1 | CASP1 2672/4885HCAR2 1038/4885ALDH1A1 3976/4885 |
| US-20210060187-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | HTT, HYPK, HSPBP1 | CASP1 2672/4885HCAR2 1038/4885ALDH1A1 3976/4885 |
| US-20190167821-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | HTT, HYPK, HSPBP1 | CASP1 2672/4885HCAR2 1038/4885ALDH1A1 3976/4885 |
| US-10765764-B2 | Probes for imaging huntingtin protein | HTT, HYPK, HSPBP1 | CASP1 2672/4885HCAR2 1038/4885ALDH1A1 3976/4885 |
| US-20150119390-A1 | IMIDAZOTHIADIAZOLE AND IMIDAZOPYRIDAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION | F2RL3, F2R, F2RL1 | CASP1 442/4885HCAR2 495/4885ALDH1A1 1921/4885 |
| US-20090137558-A1 | Pyridine based compounds useful as intermediates for pharmaceutical or agricultural end-products | PNPO, CYP4B1, PDXK | CASP1 1570/4885HCAR2 1524/4885ALDH1A1 290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.