Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 19/20 | 0.48 |
| ▸ | AR | P10275 | 6/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4207661 | 0.79 | PGR (0.53) | PGRARNR3C1NR3C2KDM4E | |
| SCHEMBL13747310 | 0.76 | PGR (0.47) | PGRARNR3C1NR3C2KDM4E | |
| SCHEMBL4189937 | 0.67 | PGR (0.67) | PGRARNR3C1NR3C2KDM4E | |
| SCHEMBL4196337 | 0.66 | PGR (0.39) | PGRARNR3C1NR3C2KDM4E | |
| SCHEMBL4183779 | 0.65 | PGR (1.00) | PGRARNR3C1NR3C2KDM4E | |
| SCHEMBL17570611 | 0.64 | TRPV4 (0.38) | AR | |
| SCHEMBL12990550 | 0.64 | KDM4E (0.46) | PGRARNR3C1NR3C2KDM4E | |
| SCHEMBL8136368 | 0.63 | ALDH1A1 (0.46) | PGRARNR3C1NR3C2KDM4E | |
| SCHEMBL20562679 | 0.63 | TSHR (0.38) | ARKDM4EALDH1A1 | |
| SCHEMBL4193682 | 0.63 | NR3C1 (0.40) | PGRARNR3C1NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103007-A2 | STEROID HORMONE RECEPTOR MODULATOR COMPOUNDS AND METHODS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2009-08-20 | — | — | WO | disclosed |
| WO-2009103007-A2 | STEROID HORMONE RECEPTOR MODULATOR COMPOUNDS AND METHODS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2009-08-20 | — | — | WO | disclosed |