Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 2/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | ACP1 | P24666 | 1/20 | 0.32 |
| ▸ | OGA | O60502 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4192495 | 0.91 | KDM4E (0.35) | ALDH1A1KDM4EHSD17B10NPC1RAB9A | |
| SCHEMBL4192472 | 0.87 | NPC1 (0.46) | CYP1A2ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4192273 | 0.85 | MAPK9 (0.39) | CYP1A2ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL4187924 | 0.85 | RAB9A (0.36) | CYP1A2ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL1005758 | 0.84 | MAPK8 (0.46) | CYP1A2ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL4190281 | 0.84 | ALDH1A1 (0.40) | CYP1A2ALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL7704544 | 0.84 | ILK (0.41) | CYP1A2ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL4185618 | 0.84 | KMT2A (0.42) | CYP1A2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL4190183 | 0.84 | MAPT (0.40) | CYP1A2ALDH1A1KDM4EHSD17B10NPC1 | |
| SCHEMBL4192264 | 0.84 | LMNA (0.40) | CYP1A2ALDH1A1NPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2026802-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | Laboratoires Serono SA (CH) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007141224-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | LABORATOIRES SERONO SA (CH) | 2007-12-13 | — | — | WO | disclosed |
| EP-1450792-A1 | BENZAZOLE DERIVATIVES FOR THE TREATMENT OF SCLERODERMA | Applied Research Systems ARS Holding N.V. (AN) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003047570-A1 | BENZAZOLE DERIVATIVES FOR THE TREATMENT OF SCLERODERMA | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2003-06-12 | — | — | WO | disclosed |
| EP-1240164-A1 | BENZAZOLE DERIVATIVES AND THEIR USE AS JNK MODULATORS | Applied Research Systems ARS Holding N.V. (AN) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001047920-A1 | BENZAZOLE DERIVATIVES AND THEIR USE AS JNK MODULATORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-07-05 | — | — | WO | disclosed |