Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.46 |
| ▸ | PTGFR | P43088 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | TEK | Q02763 | 2/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.42 |
| ▸ | PYGL | P06737 | 3/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4191839 | 0.86 | PYGL (0.39) | IDH1PTGFRKDRPYGLCNR2 | |
| SCHEMBL4199019 | 0.81 | ALDH1A1 (0.55) | KDRTEKEPHB4NPC1HPGD | |
| SCHEMBL12479066 | 0.77 | IDH1 (0.50) | IDH1PTGFRKDRTEKEPHB4 | |
| SCHEMBL14852288 | 0.77 | MAPT (0.57) | PTGFRMEN1KMT2AGPR35MAPT | |
| SCHEMBL3503509 | 0.76 | ALDH1A1 (0.50) | IDH1PTGFRKDRTEKEPHB4 | |
| SCHEMBL1242223 | 0.73 | IDH1 (0.47) | IDH1PTGFRKDRTEKEPHB4 | |
| SCHEMBL24427621 | 0.72 | IDH1 (0.48) | IDH1PTGFRKDRTEKEPHB4 | |
| SCHEMBL30832668 | 0.72 | IDH1 (0.48) | IDH1PTGFRKDRTEKEPHB4 | |
| SCHEMBL4201444 | 0.71 | ALOX15 (0.51) | RAB9ASMN1; SMN2MAPT | |
| SCHEMBL420393 | 0.70 | IDH1 (0.52) | IDH1PTGFRKDRTEKEPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090088463-A1 | Pyrazoles Useful in the Treatment of Inflammation | BIOLIPOX AB (SE) | 2009-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088463-A1 | Pyrazoles Useful in the Treatment of Inflammation | ALOX15, ALOX5, ALOX15B | IDH1 1766/4885PTGFR 554/4885KDR 4692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.