SCHEMBL4194099

SCHEMBL4194099

Cc1cc(C)c(S(=O)(=O)N[C@@H](CNC(=O)c2ccc3c(cnn3CCCNc3ncc[nH]3)c2)C(=O)O)c(C)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 20/20 1.00
ITGAV P06756 20/20 1.00
ITGA2B P08514 19/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7969198 1.00 ITGB3 (1.00) ITGB3ITGAVITGA2B
SCHEMBL30856549 1.00 ITGB3 (1.00) ITGB3ITGAVITGA2B
Trifluoroacetic Acid SCHEMBL3743186 0.96 ITGB3 (0.92) ITGB3ITGAVITGA2B
Trifluoroacetic Acid SCHEMBL3743175 0.96 ITGB3 (0.92) ITGB3ITGAVITGA2B
SCHEMBL7969271 0.94 ITGB3 (1.00) ITGB3ITGAVITGA2B
SCHEMBL7982808 0.94 ITGB3 (1.00) ITGB3ITGAVITGA2B
SCHEMBL14289059 0.92 ITGB3 (0.84) ITGB3ITGAVITGA2B
SCHEMBL14289052 0.92 ITGB3 (0.84) ITGB3ITGAVITGA2B
SCHEMBL14450438 0.91 ITGB3 (1.00) ITGB3ITGAVITGA2B
Trifluoroacetic Acid SCHEMBL7980483 0.90 ITGB3 (0.93) ITGB3ITGAVITGA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4637731-A1 COMBINATION THERAPY FOR TREATING CANCER GILEAD SCIENCES, INC. (US) 2025-10-29 EP claimed
WO-2024137442-A1 COMBINATION THERAPY FOR TREATING CANCER GILEAD SCIENCES, INC. (US) 2024-06-27 WO claimed
US-11697812-B2 Methods and compositions for the specific inhibition of transthyretin (TTR) by double-stranded RNA DICERNA PHARMACEUTICALS, INC. (US) 2023-07-11 US claimed
US-11359203-B2 Therapeutic inhibition of lactate dehydrogenase and agents therefor DICERNA PHARMACEUTICALS, INC. (US) 2022-06-14 US claimed
EP-3609434-B1 MEDICAL DEVICES COATED WITH POLYDOPAMINE AND ANTIBODIES ORBUSNEICH MEDICAL PTE LTD (SG) 2026-05-20 EP disclosed
EP-4637731-A1 COMBINATION THERAPY FOR TREATING CANCER GILEAD SCIENCES, INC. (US) 2025-10-29 EP disclosed
EP-3461809-B1 TETRACYCLINE COMPOUNDS TETRAPHASE PHARMACEUTICALS INC (US) 2025-03-26 EP disclosed
CN-119630399-A Periostin-mediated disease and prophylactic or therapeutic agent for itching associated with the disease 国立大学法人佐贺大学 2025-03-14 CN disclosed
WO-2024137442-A1 COMBINATION THERAPY FOR TREATING CANCER GILEAD SCIENCES, INC. (US) 2024-06-27 WO disclosed
WO-2024024915-A1 PROPHYLACTIC OR THERAPEUTIC AGENT FOR PERIOSTIN-MEDIATED DISEASE AND PRURITUS ASSOCIATED THEREWITH 国立大学法人佐賀大学 2024-02-01 WO disclosed
US-11873493-B2 Methods and compositions for the specific inhibition of glycolate oxidase (HAO1) by double-stranded RNA DICERNA PHARMACEUTICALS, INC. (US) 2024-01-16 US disclosed
US-11773390-B2 Methods and compositions for the specific inhibition of Complement Component 5(C5) by double-stranded RNA DICERNA PHARMACEUTICALS, INC. (US) 2023-10-03 US disclosed
CN-115137880-A Medical equipment with coating 祥丰医疗私人有限公司 2022-10-04 CN disclosed
CN-110545754-B Medical device with coating and use for treating or preventing vascular disorders 祥丰医疗私人有限公司 2022-06-28 CN disclosed
US-11359203-B2 Therapeutic inhibition of lactate dehydrogenase and agents therefor DICERNA PHARMACEUTICALS, INC. (US) 2022-06-14 US disclosed
US-11278504-B1 Treatment of a lionfish sting and formulations for use thereof PTERO TECH INC. (CA) 2022-03-22 US disclosed
CN-107257858-B Therapeutic inhibition of lactate dehydrogenase and reagents therefor 戴瑟纳制药公司 2022-03-08 CN disclosed
US-20090311266-A1 Inhibitors of the endothelin signalling pathway and alphavbeta3 integrin receptor antagonists for combination therapy BASF AKTIENGESELLSCHAFT (DE) 2009-12-17 US disclosed
EP-1239877-B1 COMPOSITION COMPRISING A TNF-ALPHA INHIBITOR AND AN INTEGRIN ALPHAVBETA3 RECEPTOR ANTAGONIST ABBOTT GMBH & CO KG (DE) 2008-01-09 EP disclosed
US-20060159678-A1 Modulators of cytokine mediated signaling pathways and integrin alphabeta3 receptor antagonists for combination therapy GENESTE HERVE 2006-07-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11278504-B1 Treatment of a lionfish sting and formulations for use thereof P2RX3, P2RX7, P2RX5 ITGB3 830/4885ITGAV 2037/4885ITGA2B 1526/4885
US-20060159678-A1 Modulators of cytokine mediated signaling pathways and integrin alphabeta3 receptor antagonists for combination therapy ITGB3, IL6ST, IL1RN ITGB3 1/4885ITGAV 11/4885ITGA2B 10/4885
US-20090311266-A1 Inhibitors of the endothelin signalling pathway and alphavbeta3 integrin receptor antagonists for combination therapy EDNRB, EDNRA, ITGB3 ITGB3 3/4885ITGAV 4/4885ITGA2B 12/4885
US-11697812-B2 Methods and compositions for the specific inhibition of transthyretin (TTR) by double-stranded RNA TTR, RNASE1, SARNP ITGB3 4011/4885ITGAV 3062/4885ITGA2B 3818/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.