Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | RRM1 | P23921 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4198739 | 0.81 | MCL1 (0.35) | MCL1FAAH | |
| SCHEMBL24164337 | 0.74 | CACNA2D1 (0.42) | MCL1DPP7RRM1FAAHGABRR1 | |
| SCHEMBL5616287 | 0.72 | GABRR1 (0.56) | GABRR1 | |
| SCHEMBL3156859 | 0.72 | GABRR1 (0.56) | GABRR1 | |
| SCHEMBL22151425 | 0.71 | GABRR1 (0.33) | GABRR1 | |
| SCHEMBL4191129 | 0.70 | GABRR1 (0.33) | GABRR1 | |
| Dimethylamine SCHEMBL7659155 | 0.69 | MCL1 (0.38) | MCL1FAAH | |
| SCHEMBL23723108 | 0.69 | GPR84 (0.61) | FAAH | |
| SCHEMBL9710237 | 0.68 | GABRR1 (0.32) | GABRR1 | |
| SCHEMBL24709076 | 0.68 | CASP2 (0.40) | DPP7FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686987-A4 | ADVANCED INDOLINONE BASED PROTEIN KINASE INHIBITORS | SCRIPPS RESEARCH INST (US) | 2009-02-25 | — | — | EP | disclosed |
| US-20080044881-A1 | Advanced Indolinone Based Protein Kinase Inhibitors | SCRIPPS RESEARCH INSTITUTE, THE | 2008-02-21 | — | — | US | disclosed |
| US-20060287381-A1 | Enhanced indolinone based protein kinase inhibitors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2006-12-21 | — | — | US | disclosed |
| EP-1686987-A2 | ADVANCED INDOLINONE BASED PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005053614-A2 | ADVANCED INDOLINONE BASED PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-06-16 | — | — | WO | disclosed |
| WO-2005053686-A1 | INDOLINONE BASED PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287381-A1 | Enhanced indolinone based protein kinase inhibitors | PHKG1, PHKG2, PRKCH | MCL1 1541/4885DPP7 2012/4885RRM1 3527/4885 |
| US-20080044881-A1 | Advanced Indolinone Based Protein Kinase Inhibitors | PHKG1, PHKG2, HIPK1 | MCL1 805/4885DPP7 2167/4885RRM1 2319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.